Baroni C D, Pezzella F, Stoppacciaro A, Mirolo M, Pescarmona E, Vitolo D, Cassano A M, Barsotti P, Nicoletti L, Ruco L P
Histopathology. 1985 Dec;9(12):1275-93. doi: 10.1111/j.1365-2559.1985.tb02810.x.
In the present study we have evaluated the histological, immunohistochemical, ultrastructural and cell surface phenotypic features of lymph nodes from 19 intravenous drug abusers and two homosexual men with persistent lymphadenopathy syndrome and from six control patients. Our investigation has demonstrated that the lymphadenopathy of drug abusers is characterized by: (a) specific histological features with evidence of evolution from an initial hyperplastic-reactive to a late regressive-destructive stage; (b) T-cell surface phenotype distribution similar to that in the peripheral blood of homosexuals; (c) peculiar infiltration of the germinal centres by T8+ cells and by S-100+, T6+ interdigitating reticulum-like cells; (d) electron microscopic features indicating the presence of virus bodies in lymph node cells and in the intercellular spaces. These data suggest that the lymphadenopathy of drug abusers and homosexuals are similar pathological conditions with characteristic features which allow histological differentiation of this entity from those found in other viral infections.
在本研究中，我们评估了19名静脉吸毒者和两名患有持续性淋巴结病综合征的同性恋男性以及6名对照患者的淋巴结的组织学、免疫组织化学、超微结构和细胞表面表型特征。我们的研究表明，吸毒者的淋巴结病具有以下特征：(a) 特定的组织学特征，有从最初的增生性反应阶段发展到后期退行性破坏阶段的证据；(b) T细胞表面表型分布与同性恋者外周血中的相似；(c) 生发中心有T8+细胞以及S-100+、T6+交错网状样细胞的特殊浸润；(d) 电子显微镜特征表明淋巴结细胞和细胞间隙中存在病毒体。这些数据表明，吸毒者和同性恋者的淋巴结病是相似的病理状况，具有特征性特征，这使得该实体在组织学上能够与其他病毒感染中的情况区分开来。
