Ran Guang-Jun, Wang Ping, Wang Hong-Kun, Wei Ting-Ting, Liu Yu-Ying, Jin Hai-Xiao, Wang Ting-Ting, He Shan
Li Dak Sum Yip Yio Chin Kenneth Li Marine Biopharmaceutical Research Center, Health Science Center, Ningbo University, Ningbo, Zhejiang, 315211, China.
Ningbo Institute of Marine Medicine, Peking University, Ningbo, Zhejiang, 315832, China.
Chem Biodivers. 2024 Dec;21(12):e202401689. doi: 10.1002/cbdv.202401689. Epub 2024 Oct 26.
Mesophotic coral ecosystems (MCEs), located at depths ranging from 30-150 m, host some of the most diverse yet least explored marine bioresources, particularly significant for the discovery of new bioactive molecules. The fungus Beauveria sp. NBUF147, associated with an Irciniidae sponge from the mesophotic zone at a depth of 82 m, underwent chemical investigation that led to the identification of one new sterol, beautoide A (1), and one reported sterol, 3β,5α,9α-trihydroxy-(22E,24R)-ergosta-7,22-dien-6-one (2). Their structures were determined from analysis of spectroscopic data and X-ray crystallography. Evaluation of biological activity in prednisolone-induced osteoporotic zebrafish showed that 1 was anti-osteoclastogenic in vivo at 3.0 μM.
中光层珊瑚生态系统（MCEs）位于30至150米深处，拥有一些最多样化但最少被探索的海洋生物资源，对于发现新的生物活性分子尤为重要。真菌白僵菌属Beauveria sp. NBUF147与来自82米深处中光层区域的一种艾氏海绵相关，经过化学研究，鉴定出一种新的甾醇，即美丽甾醇A（1），以及一种已报道的甾醇，3β,5α,9α-三羟基-(22E,24R)-麦角甾-7,22-二烯-6-酮（2）。它们的结构通过光谱数据分析和X射线晶体学确定。在泼尼松龙诱导的骨质疏松斑马鱼中进行的生物活性评估表明，1在3.0 μM时在体内具有抗破骨细胞生成作用。
