Li Dak Sum Marine Biopharmaceutical Research Center, Department of Marine Pharmacy, College of Food and Pharmaceutical Sciences, Ningbo University, Ningbo, Zhejiang, 315832, China.
College of Fisheries, Tianjin Agricultural University, Tianjin, 300392, China.
Chem Biodivers. 2022 Apr;19(4):e202200028. doi: 10.1002/cbdv.202200028. Epub 2022 Mar 9.
Mesophotic coral ecosystems (MCEs) represent an underexplored source of intriguing natural products. Efforts to discover bioactive metabolites from sponge-associated fungi in MCEs identified a new steroid, acremocholone (1) and its three known analogs (2-4), from Acremonium sp. NBUF150. The Acremonium sp. NBUF150 was isolated from a Ciocalypta sponge located 70 m deep within the South China Sea. The planar structures and absolute configuration of 1-4 were determined from NMR-derived spectroscopic data, HR-ESI-MS, and X-ray crystallography. Compound 1 exhibited antimicrobial inhibition against Vibrio scophthalmi, V. shilonii and V. brasiliensis at minimum inhibitory concentrations of 8 μg/mL; compound 2 inhibited V. shilonii and V. brasiliensis at 8 and 32 μg/mL, respectively, and compound 4 inhibited growth of V. brasiliensis at 16 μg/mL. Sponge associated fungi from MCEs represent a promising resource of anti-Vibrio drug leads for aquaculture use.
中光层珊瑚礁生态系统 (MCEs) 是一类尚未充分开发的有趣天然产物资源。为了从 MCEs 中海绵共生真菌中发现具有生物活性的代谢产物，从南海 70 米深处的 Ciocalypta 海绵中分离得到的 Acremonium sp. NBUF150 中鉴定出一种新甾体 acremocholone (1) 及其三个已知类似物 (2-4)。Acremonium sp. NBUF150 的平面结构和绝对构型是通过 NMR 衍生的光谱数据、高分辨电喷雾电离质谱 (HR-ESI-MS) 和 X 射线晶体学确定的。化合物 1 对最小抑菌浓度为 8 μg/mL 的创伤弧菌、灿烂弧菌和副溶血弧菌表现出抗菌抑制作用；化合物 2 对灿烂弧菌和副溶血弧菌的抑制作用分别为 8 和 32 μg/mL，化合物 4 对副溶血弧菌的生长抑制作用为 16 μg/mL。MCEs 中的海绵共生真菌是水产养殖中抗弧菌药物的有前途的来源。
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