Departamento de Biotecnología, Centro de Desarrollo de Productos Bióticos, Instituto Politécnico Nacional, Yautepec, C.P.62730, Morelos, México.
Instituto Politécnico Nacional, CICATA Morelos, 62720, Atlacholoaya, Morelos, Mexico.
Plant Foods Hum Nutr. 2024 Dec;79(4):803-809. doi: 10.1007/s11130-024-01218-2. Epub 2024 Aug 13.
Peptic ulcers (PU) are a breach in the mucosa of the digestive tract and are related to several factors including an altered immune system and an unbalanced diet. Current treatment carries to long-term complications; therefore, the use of medicinal plants is an alternative for several inflammatory diseases including ulcerative lesions. Kalanchoë gastonis-bonnieri, is a succulent plant and, has been used in traditional medicine against gastric ulcers, inflammation, and cancer among others. The main goal of this work was to analyze the anti-ulcerogenic potential of extracts from leaves of K. gastonis-bonnieri in an assay of ethanol-induced gastric ulcers. An ethanolic extract was obtained by maceration from fresh leaves of K. gastonis-bonnieri, and fractions were obtained through bipartition and chemical fractioning. The chemical characterization of the extract was made through HPLC, GC-MS, and NMR. Total extract and fractions showed an anti-ulcerogenic effect in specimens of male ICR mice with a gastric ulcer index (UI) of 3.27-5.47. The recorded effect is attributed to the presence of terpenoid compounds such as β-Amyrin acetate, which showed antioxidant properties and lessened formations of ulcers induced by ethanol administration in mice stomach.
消化性溃疡（PU）是消化道黏膜的破裂，与免疫系统改变和饮食失衡等多种因素有关。目前的治疗方法存在长期并发症；因此，药用植物的使用是治疗多种炎症性疾病（包括溃疡性病变）的一种替代方法。加斯顿氏落地生根（Kalanchoë gastonis-bonnieri）是一种肉质植物，已在传统医学中用于治疗胃溃疡、炎症和癌症等疾病。这项工作的主要目标是分析加斯顿氏落地生根叶提取物对乙醇诱导的胃溃疡的抗溃疡潜力。通过从新鲜的加斯顿氏落地生根叶中进行浸提获得了一种乙醇提取物，并通过二相分配和化学分级获得了馏分。通过 HPLC、GC-MS 和 NMR 对提取物进行了化学表征。总提取物和馏分在雄性 ICR 小鼠的胃溃疡指数（UI）为 3.27-5.47 的标本中表现出抗溃疡作用。记录到的作用归因于萜类化合物的存在，如乙酸-β-香树脂醇，它具有抗氧化特性，可减少乙醇给药引起的小鼠胃溃疡的形成。
