Gallegos Julian L, Taylor-Piliae Ruth E, Pace Thaddeus W W, Gallek Matthew J, Ritter Leslie
School of Nursing, Purdue University, West Lafayette, IN, USA.
College of Nursing, University of Arizona, Tucson, AZ, USA.
SAGE Open Nurs. 2024 Aug 12;10:23779608241272513. doi: 10.1177/23779608241272513. eCollection 2024 Jan-Dec.
Filipino Americans (FAs) are at high risk for developing type 2 diabetes despite other Asian phenotypes. Evidence suggests that pro-inflammatory interleukin-18 (IL-18) and anti-inflammatory adiponectin biomarkers associated with visceral adipose tissue (VAT) may explain this risk.
This study aimed to quantify the biomarkers in relation to standard ranges of VAT or typical circulating concentration ranges reported in the literature of IL-18 and adiponectin, examine relationships of these markers, and determine if they were different among those participants without diabetes, prediabetes, and diabetes.
A cross-sectional study was used to enroll FAs without diabetes, prediabetes, or diabetes. VAT was measured using the InBody 570 Body Composition Analyzer. Blood samples were obtained to assess plasma concentrations of IL-18 and adiponectin using enzyme-linked immunosorbent assay. All analyses were conducted using a 5% type I error rate. Mean ±SD and percentages were used to describe the sample and data where appropriate. Pearson's correlations (R) were calculated to determine the relationships between VAT and IL-18 in each group. Analysis of variance was used to determine differences in VAT, IL-18, and adiponectin among groups. Further, nonparametric procedures examined the differences in adiponectin among those within groups.
Seventy-five participants were enrolled. Biomarkers above the typical concentration range were observed for VAT, IL-18, and adiponectin. Adiponectin significantly differed among groups with lower values in the diabetes group vs. the nondiabetes group.
The findings indicate that while inflammation-related biomarkers, such as adiponectin, correlate with VAT and may serve as indicators of increased risk of type 2 diabetes in FAs, correlation alone does not establish causality.
尽管菲律宾裔美国人（FAs）具有其他亚洲人的表型特征，但他们患2型糖尿病的风险很高。有证据表明，与内脏脂肪组织（VAT）相关的促炎细胞因子白细胞介素-18（IL-18）和抗炎性脂联素生物标志物可能解释了这种风险。
本研究旨在量化与VAT标准范围或文献报道的IL-18和脂联素典型循环浓度范围相关的生物标志物，研究这些标志物之间的关系，并确定它们在无糖尿病、糖尿病前期和糖尿病的参与者中是否存在差异。
采用横断面研究招募无糖尿病、糖尿病前期或糖尿病的FAs。使用InBody 570人体成分分析仪测量VAT。采集血样，采用酶联免疫吸附测定法评估血浆中IL-18和脂联素的浓度。所有分析均采用5%的I型错误率。在适当情况下，使用均值±标准差和百分比来描述样本和数据。计算Pearson相关性（R）以确定每组中VAT与IL-18之间的关系。采用方差分析来确定各组之间VAT、IL-18和脂联素的差异。此外，采用非参数检验方法检查组内脂联素的差异。
共招募了75名参与者。观察到VAT、IL-18和脂联素的生物标志物高于典型浓度范围。糖尿病组与非糖尿病组相比，脂联素在各组间存在显著差异，糖尿病组的值较低。
研究结果表明，虽然脂联素等与炎症相关的生物标志物与VAT相关，可能作为菲律宾裔美国人患2型糖尿病风险增加的指标，但仅相关性并不能确立因果关系。
