Russo Vincenzo, Pecori Filippo, Colalillo Nicola, Massimo Nicola, Valentino Giovanni Battista, Comune Angelo, Parente Erika, Nigro Gerardo
Department of Translational Medical Sciences, Cardiology and Syncope Unit, University of Campania "Luigi Vanvitelli" - Monaldi Hospital, 80131 Naples, Italy.
Rev Cardiovasc Med. 2024 Jul 15;25(7):264. doi: 10.31083/j.rcm2507264. eCollection 2024 Jul.
Neurally mediated reflex syncope (NMRS) has been recently described as a possible trigger of Takotsubo syndrome (TTS). There are few data in the literature about this association.
In the present meta-summary, 6 case reports describing patients who experienced TTS following an NMRS episode were included. Patient characteristics, triggers and type of syncope were collected.
A total of 7 patients with a median age of 63.4 years (interquartile range, IQR: 47.5-76) were evaluated; 71.4% were females, mainly in the menopausal state (80%). The TTS triggers were: vasovagal syncope in 6 patients (85.7%) and situational syncope in 1 patient (14.3%). 2 patients underwent a comprehensive clinical evaluation which showed a cardioinhibitory response.
NMRS due to sudden orthostatism and emotional stress, mainly with a cardioinhibitory response, has been associated with the onset of TTS, in particular among female patients in a menopausal state.
神经介导的反射性晕厥（NMRS）最近被描述为应激性心肌病（TTS）的一种可能诱因。关于这种关联，文献中的数据很少。
在本荟萃综述中，纳入了6例描述NMRS发作后发生TTS患者的病例报告。收集了患者的特征、诱因和晕厥类型。
共评估了7例患者，中位年龄为63.4岁（四分位间距，IQR：47.5 - 76）；71.4%为女性，主要处于绝经状态（80%）。TTS的诱因包括：6例患者为血管迷走性晕厥（85.7%），1例患者为情境性晕厥（14.3%）。2例患者接受了全面的临床评估，显示为心脏抑制反应。
由突然直立和情绪应激引起的NMRS，主要表现为心脏抑制反应，与TTS的发作有关，尤其是在绝经状态的女性患者中。
