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机器人辅助根治性膀胱切除术后输尿管肠吻合口狭窄的机器人辅助输尿管肠再植术:二十年的手术方法及结果

Robot-assisted uretero-enteric reimplantation for uretero-enteric anastomotic strictures following robot-assisted radical cystectomy: Surgical approach and outcomes over two decades.

作者信息

Mahmood Abdul Wasay, Harrington Grace, Jing Zhe, Li Qiang, Hussein Ahmed A, Guru Khurshid A

机构信息

Department of Urology, Roswell Park Comprehensive Cancer Center, Elm and Carlton Streets, Buffalo, New York, NY, USA.

出版信息

Asian J Urol. 2024 Jul;11(3):384-390. doi: 10.1016/j.ajur.2023.10.002. Epub 2024 Feb 7.

Abstract

OBJECTIVE

We described the technique and outcomes of robot-assisted repair of uretero-enteric strictures (UES) following robot-assisted radical cystectomy (RARC) and urinary diversion.

METHODS

Retrospective review of our RARC database from November 2005 to August 2023 at Roswell Park Comprehensive Cancer center was performed. Patients who developed UES and ultimately underwent robot-assisted uretero-enteric reimplantation (RUER) were identified. Kaplan-Meier method was used to compute the cumulative incidence recurrence rate of UES after RUER. A multivariable regression model was used to identify variables associated with UES recurrence.

RESULTS

A total of 123 (15%) out of 808 RARC patients developed UES, of whom 52 underwent reimplantation (45 patients underwent RUER [=55 cases] and seven patients underwent open uretero-enteric reimplantation). The median time from RARC to UES was 4.4 (interquartile range 3.0-7.0) months, and the median time between UES and RUER was 5.2 (interquartile range 3.2-8.9) months. The 3-year recurrence rate after RUER is about 29%. On multivariable analysis, longer hospital stay (hazard ratio 1.37, 95% confidence interval 1.16-1.61, <0.01) was associated with recurrent UES after RUER.

CONCLUSION

RUER for UES after RARC is feasible with durable outcomes although a notable subset of patients experienced postoperative complications and UES recurrence.

摘要

目的

我们描述了机器人辅助根治性膀胱切除术(RARC)及尿流改道后机器人辅助修复输尿管肠吻合口狭窄(UES)的技术及结果。

方法

对罗斯威尔帕克综合癌症中心2005年11月至2023年8月的RARC数据库进行回顾性分析。确定发生UES并最终接受机器人辅助输尿管肠再植术(RUER)的患者。采用Kaplan-Meier法计算RUER后UES的累积发病率复发率。使用多变量回归模型确定与UES复发相关的变量。

结果

808例RARC患者中共有123例(15%)发生UES,其中52例接受了再植术(45例接受RUER[=55例],7例接受开放输尿管肠再植术)。从RARC到UES的中位时间为4.4(四分位间距3.0 - 7.0)个月,从UES到RUER的中位时间为5.2(四分位间距3.2 - 8.9)个月。RUER后3年复发率约为29%。多变量分析显示,住院时间延长(风险比1.37,95%置信区间1.16 - 1.61,P<0.01)与RUER后UES复发相关。

结论

RARC术后UES行RUER是可行的,预后持久,尽管有相当一部分患者经历了术后并发症和UES复发。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7fb5/11318451/521ec34a2ed9/gr1.jpg

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