An Nguyen Van, Kien Hoang Trung, Hoang Le Huy, Cuong Nguyen Hung, Quang Hoang Xuan, Le Tuan Dinh, Thang Ta Ba, Viet Tien Tran, Thuc Luong Cong, Hung Dinh Viet, Viet Nguyen Hoang, Minh Le Nhat, Luong Vu Huy, Nguyen Vinh Thi Ha, Hoa Pham Quynh, Le Hai Ha Long
Department of Microbiology, Military Hospital 103, Vietnam Military Medical University, Hanoi, Vietnam.
Department of Immunology, Vietnam Military Medical University, Hanoi, Vietnam.
Infect Drug Resist. 2024 Aug 9;17:3463-3473. doi: 10.2147/IDR.S472025. eCollection 2024.
At a teaching Hospital in Vietnam, the persistently high incidence of diagnosed wound infection poses ongoing challenges to treatment. This study seeks to explore the causative agents of wound infection and their antimicrobial and multidrug resistance patterns.
A cross-sectional study was conducted at the Department of Microbiology, Military Hospital 103, Vietnam. Data on microorganisms that caused wound infection and their antimicrobial resistance patterns was recorded from hospitalized patients from 2014 to 2021. Using the chi-square test, we analyzed the initial isolation from wound infection specimens collected from individual patients.
Over a third (34.9%) of wound infection samples yielded bacterial cultures. was the most prevalent bacteria, followed by . Worryingly high resistance rates were observed for several antibiotics, particularly among Gram-negative bacteria. Ampicillin displayed the highest resistance (91.9%), while colistin and ertapenem remained the most effective. In Gram-positive bacteria, glycopeptides like teicoplanin and vancomycin (0% and 3.3% resistance, respectively) were most effective, but their use was limited. Clindamycin and tetracycline showed decreasing effectiveness. Resistance rates differed between surgical and non-surgical wards, highlighting the complex dynamics of antimicrobial resistance within hospitals. Multidrug resistance (MDR) was substantial, with Gram-negative bacteria exhibiting a 63.6% MDR rate. showed the highest MDR rate (88.0%).
This study investigated wound infection characteristics, antibiotic resistance patterns of common bacteria, and variations by hospital ward. was the most prevalent bacteria, and concerning resistance rates were observed, particularly among Gram-negative bacteria. These findings highlight the prevalence of multidrug resistance in wound infections, emphasizing the importance of infection control measures and judicious antibiotic use.
在越南的一家教学医院，确诊伤口感染的持续高发病率给治疗带来了持续挑战。本研究旨在探索伤口感染的病原体及其抗菌和多重耐药模式。
在越南第103军事医院微生物科进行了一项横断面研究。记录了2014年至2021年住院患者中导致伤口感染的微生物及其抗菌耐药模式的数据。使用卡方检验，我们分析了从个体患者伤口感染标本中进行的初次分离。
超过三分之一（34.9%）的伤口感染样本培养出细菌。 是最常见的细菌，其次是 。观察到几种抗生素的耐药率高得令人担忧，尤其是在革兰氏阴性菌中。氨苄西林的耐药率最高（91.9%），而黏菌素和厄他培南仍然是最有效的。在革兰氏阳性菌中，替考拉宁和万古霉素等糖肽类抗生素（耐药率分别为0%和3.3%）最有效，但它们的使用有限。克林霉素和四环素的有效性在下降。手术病房和非手术病房的耐药率有所不同，突出了医院内抗菌耐药的复杂动态。多重耐药（MDR）情况严重，革兰氏阴性菌的多重耐药率为63.6%。 显示出最高的多重耐药率（88.0%）。
本研究调查了伤口感染特征、常见细菌的抗生素耐药模式以及不同医院病房的差异。 是最常见的细菌，观察到令人担忧的耐药率，尤其是在革兰氏阴性菌中。这些发现突出了伤口感染中多重耐药的普遍性，强调了感染控制措施和合理使用抗生素的重要性。
