印记基因的 DNA 甲基化进展及叶酸对生长发育的调控。
Advances in DNA methylation of imprinted genes and folic acid regulation of growth and development.
机构信息
Department of Biostatistics, School of Public Health & Management, Guangxi Traditional Chinese Medical University, Nanning, Guangxi, China.
Department of Neurology, The First Affiliated Hospital of Guangxi Traditional Chinese Medical University, Nanning, Guangxi, China.
出版信息
Epigenomics. 2024;16(15-16):1117-1127. doi: 10.1080/17501911.2024.2384833. Epub 2024 Aug 14.
Abstract
DNA methylation is closely related to folate levels and acts as a mechanism linking developmental disorders to chronic diseases. Folic acid supplementation can impact DNA methylation levels of imprinted genes crucial for neonatal development. Imprinted genes are vital for regulating embryonic and postnatal fetal growth. This review summarizes imprinted genes, DNA methylation, folic acid's influence on growth and development and their correlation. It aims to provide a comprehensive overview of research advancements on imprinted genes, DNA methylation and folic acid regulation concerning growth and development.
摘要
DNA 甲基化与叶酸水平密切相关，是将发育障碍与慢性疾病联系起来的一种机制。叶酸补充可以影响新生儿发育关键的印迹基因的 DNA 甲基化水平。印迹基因对于调节胚胎和产后胎儿生长至关重要。本综述总结了印迹基因、DNA 甲基化、叶酸对生长发育的影响及其相关性。旨在提供关于印迹基因、DNA 甲基化和叶酸调节生长发育的研究进展的全面概述。
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