美国成年人中龋齿与血清 CRP 之间的关联：来自 NHANES 2015-2018 的证据。

The association between dental caries and serum crp in the us adult population: evidence from NHANES 2015-2018.

机构信息

Ministry of Health Kuwait, Jamal Abdel Nasser Street, Sulaibikhat, 13001, Kuwait.

College of Dentistry, King Saud University, Riyadh, Saudi Arabia.

出版信息

BMC Public Health. 2024 Aug 14;24(1):2210. doi: 10.1186/s12889-024-19681-6.

DOI:10.1186/s12889-024-19681-6

PMID:39143473

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11323639/

Abstract

BACKGROUND

Dental caries remains one of the most prevalent diseases worldwide, affecting 29.4% of the global population. Despite numerous efforts to diagnose, predict, and prevent dental caries, the incidence continues to rise. Salivary biomarkers provide a non-invasive means for early detection of various oral conditions. C-reactive protein (CRP) is a key marker, elevated in both oral and general inflammatory conditions such as diabetes, periodontitis and oral squamous cell carcinoma. Considering the emerging connection between oral and systemic health, it is worth exploring the various factors associated with this widespread disease. This study investigates the association between CRP levels and dental caries in the United States population, utilizing data from the National Health and Nutrition Examination Survey (NHANES).

METHODS

The study analyzed data from the 2015-2018 NHANES cycles, focusing on a nationally representative sample of individuals aged 30 years and above. Weighted multivariable negative binomial and logistic regression analyses were employed to explore the relationship between dental caries and CRP levels, adjusting for age, gender, race, education level, diabetes status, and gum disease.

RESULTS

The results of the negative binomial regression analysis demonstrated a positive association between higher CRP levels and an increased mean number of dental caries (Adjusted Mean Ratio [AMR] = 1.7; 95% CI: 1.3 - 2; P: < 0.001). The logistic regression analysis showed that individuals with higher CRP levels have a 50% increase in the odds of developing dental caries (AOR: 1.5, CI: 1.2 - 1.9; P: < 0.01).

CONCLUSION

The results of this cross-sectional study of the U.S. population highlight the positive association between high CRP levels and increased dental caries. These findings contribute to the growing body of evidence supporting the integration of oral and systemic health care. Further research is necessary to deepen our understanding of the mechanistic relationship between CRP levels and dental caries.

摘要

背景

龋齿仍然是全球最普遍的疾病之一，影响了全球 29.4%的人口。尽管人们做出了诸多努力来诊断、预测和预防龋齿，但发病率仍在上升。唾液生物标志物为各种口腔状况的早期检测提供了一种非侵入性手段。C 反应蛋白（CRP）是一个关键标志物，在口腔和全身性炎症性疾病如糖尿病、牙周炎和口腔鳞状细胞癌中都会升高。鉴于口腔健康和全身健康之间日益紧密的联系，值得探索与这种广泛存在的疾病相关的各种因素。本研究利用美国国家健康和营养检查调查（NHANES）的数据，研究了 CRP 水平与美国人群中龋齿之间的关联。

方法

该研究分析了 2015-2018 年 NHANES 周期的数据，重点关注年龄在 30 岁及以上的具有全国代表性的个体样本。采用加权多变量负二项式和逻辑回归分析来探讨龋齿和 CRP 水平之间的关系，同时调整年龄、性别、种族、教育程度、糖尿病状况和牙龈疾病。

结果

负二项回归分析的结果表明，CRP 水平较高与龋齿平均数量增加之间存在正相关（调整后的平均比[AMR] = 1.7；95%CI：1.3 - 2；P： < 0.001）。逻辑回归分析表明，CRP 水平较高的个体发生龋齿的几率增加了 50%（优势比[AOR]：1.5，CI：1.2 - 1.9；P： < 0.01）。