Alamoudi Ahmed, Alamoudi Raghad, Gazzaz Yara, Alqahtani Aseel M
Department of Oral Biology, Faculty of Dentistry, King Abdulaziz University, Jeddah 21589, Saudi Arabia.
General Dentistry, Faculty of Dentistry, King Abdulaziz University, Jeddah 21589, Saudi Arabia.
Diagnostics (Basel). 2022 Dec 7;12(12):3080. doi: 10.3390/diagnostics12123080.
Saliva plays a significant role in oral health and tooth integrity. Salivary components reduce tooth surface exposure to demineralization, protect against teeth wear and aid in enamel remineralization. There is a growing attempt to use salivary markers in diagnosing or predicting caries. However, despite the current information, there has yet to be an agreement among scholars. This study seeks to contribute more evidence on the suitability of salivary biomarkers in dental caries diagnosis. Eligible studies were electronically searched on online databases PubMed, Elsevier's Scopus, EMBASE and Web of Science, and all the studies that met the inclusion criteria were considered. The PECOS criteria guided the study selection process based on the study question. The risk of bias was assessed using the STROBE checklist. Eighteen articles were included in the analysis. All the studies presented relevant data concerning the study objectives. There was evidence of associations between salivary biomarkers and dental caries, and the correlations were either positive or negative. The studies presented significant heterogeneity; thus, a meta-analysis was not possible. Salivary biomarkers appeared to perform crucial and complementary functions toward tooth integrity and thus may be reliable in predicting or diagnosing dental caries in patients.
唾液在口腔健康和牙齿完整性方面发挥着重要作用。唾液成分可减少牙齿表面脱矿的暴露，防止牙齿磨损，并有助于牙釉质再矿化。目前越来越多地尝试使用唾液标志物来诊断或预测龋齿。然而，尽管有当前的这些信息，但学者们尚未达成共识。本研究旨在为唾液生物标志物在龋齿诊断中的适用性提供更多证据。通过在在线数据库PubMed、爱思唯尔的Scopus、EMBASE和科学网进行电子检索，查找符合条件的研究，并纳入所有符合纳入标准的研究。PECOS标准基于研究问题指导研究选择过程。使用STROBE清单评估偏倚风险。18篇文章纳入分析。所有研究均提供了与研究目标相关的数据。有证据表明唾液生物标志物与龋齿之间存在关联，且相关性为正或负。这些研究呈现出显著的异质性；因此，无法进行荟萃分析。唾液生物标志物似乎对牙齿完整性起着关键和补充作用，因此在预测或诊断患者龋齿方面可能是可靠的。
