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系统性红斑狼疮各表型中细胞特异性转座元件与基因表达分析

Cell-Specific Transposable Element and Gene Expression Analysis Across Systemic Lupus Erythematosus Phenotypes.

作者信息

Cutts Zachary, Patterson Sarah, Maliskova Lenka, Taylor Kimberly E, Ye Chun Jimmie, Dall'Era Maria, Yazdany Jinoos, Criswell Lindsey A, Fragiadakis Gabriela K, Langelier Charles, Capra John A, Sirota Marina, Lanata Cristina M

机构信息

University of California, San Francisco, San Francisco.

National Human Genome Research Institute, NIH, Bethesda, Maryland.

出版信息

ACR Open Rheumatol. 2024 Nov;6(11):769-779. doi: 10.1002/acr2.11713. Epub 2024 Aug 14.

DOI:10.1002/acr2.11713
PMID:39143499
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11557995/
Abstract

OBJECTIVE

There is an established yet unexplained link between interferon (IFN) and systemic lupus erythematosus (SLE). The expression of sequences derived from transposable elements (TEs) may contribute to SLE phenotypes, specifically production of type I IFNs and generation of autoantibodies.

METHODS

We profiled cell-sorted RNA-sequencing data (CD4 T cells, CD14 monocytes, CD19 B cells, and natural killer cells) from peripheral blood mononuclear cells of 120 patients with SLE and quantified TE expression identifying 27,135 TEs. We tested for differential TE expression across 10 SLE phenotypes, including autoantibody production and disease activity.

RESULTS

We found 731 differentially expressed (DE) TEs across all SLE phenotypes that were mostly cell specific and phenotype specific. DE TEs were enriched for specific families and open reading frames of viral genes encoded in TE sequences. Increased expression of DE TEs was associated with genes involved in antiviral activity, such as LY6E, ISG15, and TRIM22, and pathways such as IFN signaling.

CONCLUSION

These findings suggest that expression of TEs contributes to activation of SLE-related mechanisms in a cell-specific manner, which can impact disease diagnostics and therapeutics.

摘要

目的

干扰素（IFN）与系统性红斑狼疮（SLE）之间存在一种既定但尚未解释清楚的联系。转座元件（TEs）衍生序列的表达可能导致SLE的表型，特别是I型IFN的产生和自身抗体的生成。

方法

我们分析了120例SLE患者外周血单个核细胞经细胞分选后的RNA测序数据（CD4 T细胞、CD14单核细胞、CD19 B细胞和自然杀伤细胞），并对TE表达进行定量，共鉴定出27,135个TEs。我们检测了10种SLE表型中TE的差异表达，包括自身抗体产生和疾病活动度。

结果

我们在所有SLE表型中发现了731个差异表达的TEs，它们大多具有细胞特异性和表型特异性。差异表达的TEs在TE序列中编码的病毒基因的特定家族和开放阅读框中富集。差异表达的TEs表达增加与抗病毒活性相关基因（如LY6E、ISG15和TRIM22）以及IFN信号通路等途径有关。

结论

这些发现表明，TEs的表达以细胞特异性方式促进SLE相关机制的激活，这可能影响疾病的诊断和治疗。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7020/11557995/249faa65af2a/ACR2-6-769-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7020/11557995/a80a85c11de5/ACR2-6-769-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7020/11557995/faa134d6425b/ACR2-6-769-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7020/11557995/73bd317067ea/ACR2-6-769-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7020/11557995/1610ae72e641/ACR2-6-769-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7020/11557995/249faa65af2a/ACR2-6-769-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7020/11557995/a80a85c11de5/ACR2-6-769-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7020/11557995/faa134d6425b/ACR2-6-769-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7020/11557995/73bd317067ea/ACR2-6-769-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7020/11557995/1610ae72e641/ACR2-6-769-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7020/11557995/249faa65af2a/ACR2-6-769-g005.jpg

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2
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BMC Med Genomics. 2023 Apr 3;16(1):68. doi: 10.1186/s12920-023-01486-y.
3
Pathogenesis of systemic lupus erythematosus: risks, mechanisms and therapeutic targets.
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Ann Rheum Dis. 2023 Aug;82(8):999-1014. doi: 10.1136/ard-2022-223741. Epub 2023 Feb 15.
4
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5
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6
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