Baek Gwangin, Lee Yong-Jin, Kwon Soon-Chan, Min Young-Sun, Yun Jisuk, Ahn Tae Jin, Jang Eun-Chul
Department of Occupational and Environmental Medicine, Soonchunhyang University Cheonan Hospital, Cheonan, Korea.
Ann Occup Environ Med. 2024 Jul 10;36:e18. doi: 10.35371/aoem.2024.36.e18. eCollection 2024.
Disturbance of circadian rhythms caused by shift work has adverse effects on insulin resistance. Many previous studies have confirmed that shift work and insulin resistance are related using homeostasis model assessment-insulin resistance, one of the insulin resistance indicators. However, the triglycerides and glucose index (TyG index) has recently been studied as an insulin resistance indicator. The aim of this study is to investigate the association of shift work and TyG index, one of the indirect indicators of insulin resistance, using results of health checkups in one workplace.
Based on medical examination data collected in February 2019, a total of 3,794 subjects from one chemical plant in Korea were selected for this study. Cut-off value of TyG index for predicting development of diabetes mellitus (DM) was 4.69. A multiple logistic regression analysis was performed after adjusting for age, employment period, obesity, abdominal obesity, smoking, drinking, physical activity, hypertension, stroke, heart disease.
As a result of logistic regression analysis, compared to day workers, odds ratio (OR) with a TyG index above cut-off value for predicting development of DM in shift workers was 1.220 after adjusting for age, employment period, obesity, abdominal obesity, smoking, drinking, physical activity, hypertension, stroke, heart disease (Model 1, OR: 1.276; 95% confidence interval [CI]: 1.099-1.482; Model 2, OR: 1.232; 95% CI: 1.055-1.438; Model 3, OR: 1.220, 95% CI: 1.030-1.444).
There was a significant association between shift work and TyG index among male workers in a chemical plant. More research studies on the association between shift work and TyG index are needed in the future.
轮班工作导致的昼夜节律紊乱对胰岛素抵抗有不良影响。许多先前的研究使用胰岛素抵抗指标之一的稳态模型评估-胰岛素抵抗，证实了轮班工作与胰岛素抵抗有关。然而，甘油三酯与血糖指数（TyG指数）最近作为一种胰岛素抵抗指标受到研究。本研究的目的是利用一个工作场所的健康检查结果，调查轮班工作与胰岛素抵抗间接指标之一的TyG指数之间的关联。
基于2019年2月收集的体检数据，本研究选取了韩国一家化工厂的3794名受试者。预测糖尿病（DM）发生的TyG指数临界值为4.69。在对年龄、工作年限、肥胖、腹型肥胖、吸烟、饮酒、身体活动、高血压、中风、心脏病进行校正后，进行多因素逻辑回归分析。
逻辑回归分析结果显示，与日班工人相比，在对年龄、工作年限、肥胖、腹型肥胖、吸烟、饮酒、身体活动、高血压、中风、心脏病进行校正后，轮班工人中TyG指数高于临界值预测DM发生的比值比（OR）为1.220（模型1，OR：1.276；95%置信区间[CI]：1.099-1.482；模型2，OR：1.232；95%CI：1.055-1.438；模型3，OR：1.220，95%CI：1.030-1.444）。
化工厂男性工人中轮班工作与TyG指数之间存在显著关联。未来需要更多关于轮班工作与TyG指数之间关联的研究。
