Heo Hee Sun, Kim Yeong Eun, Lee Jong Hun
Department of Food Science and Biotechnology, College of Life Sciences, CHA University, Gyeonggi-do, 11160 Republic of Korea.
Orion Jeju Yongamsoo, Jeju, 63359 Republic of Korea.
Food Sci Biotechnol. 2024 Feb 25;33(11):2653-2661. doi: 10.1007/s10068-023-01510-y. eCollection 2024 Aug.
Reactive oxygen species (ROS) are associated with various pathological conditions, including atherosclerosis and cancer. Photoaging, mainly caused by UVB-induced ROS, accelerates skin aging and collagen degradation. Nuclear factor erythroid 2-related factor 2 (Nrf2) regulates antioxidant enzymes and has demonstrated protective effects against chronic diseases. Jeju lava seawater (JLS), which is rich in minerals, is attracting attention for its health benefits. The current study investigates the antioxidant properties of JLS in human dermal fibroblasts (HDFs). experiments were conducted by culturing HDFs in JLS with different water hardness levels and irradiating UVB. The results show that JLS does not affect HDF viability, especially at high water hardness. JLS treatment enhances collagen production and upregulates Nrf2 and antioxidant enzymes such as NQO1 and HO-1. This mechanism involves the translocation of Nrf2 to the cell nucleus. JLS shows promise as an antioxidant, potentially mitigating the effects of oxidative stress and promoting collagen synthesis.
活性氧（ROS）与多种病理状况相关，包括动脉粥样硬化和癌症。光老化主要由紫外线B（UVB）诱导的ROS引起，会加速皮肤老化和胶原蛋白降解。核因子红细胞2相关因子2（Nrf2）调节抗氧化酶，并已证明对慢性疾病具有保护作用。富含矿物质的济州岛火山熔岩海水（JLS）因其对健康有益而受到关注。当前研究调查了JLS在人皮肤成纤维细胞（HDFs）中的抗氧化特性。通过在不同水硬度水平的JLS中培养HDFs并照射UVB来进行实验。结果表明，JLS不影响HDF的活力，尤其是在高水硬度下。JLS处理可增强胶原蛋白的产生，并上调Nrf2以及NQO1和HO-1等抗氧化酶。该机制涉及Nrf2向细胞核的转位。JLS有望作为一种抗氧化剂，潜在地减轻氧化应激的影响并促进胶原蛋白合成。
