在HAPIEE研究的波兰成年人中，膳食多酚与代谢综合征呈负相关。
Dietary polyphenols are inversely associated with metabolic syndrome in Polish adults of the HAPIEE study.
作者信息
Grosso Giuseppe, Stepaniak Urszula, Micek Agnieszka, Stefler Denes, Bobak Martin, Pająk Andrzej
机构信息
Integrated Cancer Registry of Catania-Messina-Siracusa-Enna, Azienda Ospedaliero Universitaria Policlinico Vittorio Emanuele, Via S. Sofia 85, 95123, Catania, Italy.
Department of Epidemiology and Population Studies, Jagiellonian University Medical College, Kraków, Poland.
出版信息
Eur J Nutr. 2017 Jun;56(4):1409-1420. doi: 10.1007/s00394-016-1187-z. Epub 2016 Feb 25.
PURPOSE
The aim of this study was to evaluate the association between total and individual classes and subclasses of dietary polyphenol intake and prevalence of metabolic syndrome (MetS) in the Polish arm of the Health, Alcohol and Psychosocial factors In Eastern Europe cohort study.
METHODS
A cross-sectional population-based survey including 8821 adults (51.4 % female) was conducted in Kraków, Poland. Dietary polyphenol intake was evaluated using food frequency questionnaires and matching food consumption data with the Phenol-Explorer database. MetS was defined according to the International Diabetes Federation definition. Linear and logistic regression models were performed to estimate odds ratios (ORs) and confidence intervals (CIs).
RESULTS
Significant differences in age and energy intake among different categories of total dietary polyphenol intake were found. Body mass index (BMI), waist circumference (WC), blood pressure, and triglycerides were significantly lower among individuals in the higher quartiles of polyphenol intake, but a linear association was found only for BMI and WC. After adjusting for potential confounding factors, individuals in the highest quartile of polyphenol intake were less likely to have MetS (OR 0.80; 95 % CI 0.64, 0.98 and OR 0.70; 95 % CI 0.56, 0.86 for both men and women, respectively). High total polyphenol intake was negatively associated with WC, blood pressure, high lipoprotein cholesterol, and triglycerides in women, and fasting plasma glucose in both genders. Among individual classes of polyphenols, phenolic acids and stilbenes were significantly associated with MetS; lignans and stilbenes with WC; phenolic acids with blood pressure and triglycerides; and flavonoids with fasting plasma glucose. Among specific subclasses of polyphenols, hydroxycinnamic acids, flavanols, and dihydrochalcones had the most relevant role.
CONCLUSIONS
Total and individual classes and subclasses of dietary polyphenols were inversely associated with MetS and some of its components.
目的
在东欧队列研究的波兰分支中，本研究旨在评估膳食多酚总摄入量及各类别和亚类与代谢综合征（MetS）患病率之间的关联。
方法
在波兰克拉科夫开展了一项基于人群的横断面调查，纳入8821名成年人（51.4%为女性）。使用食物频率问卷评估膳食多酚摄入量，并将食物消费数据与酚类物质探索者数据库进行匹配。根据国际糖尿病联盟的定义来界定代谢综合征。采用线性和逻辑回归模型来估计比值比（OR）和置信区间（CI）。
结果
不同膳食多酚总摄入量类别之间在年龄和能量摄入方面存在显著差异。在多酚摄入量处于较高四分位数的个体中，体重指数（BMI）、腰围（WC）、血压和甘油三酯显著较低，但仅发现BMI和WC存在线性关联。在对潜在混杂因素进行调整后，多酚摄入量处于最高四分位数的个体患代谢综合征的可能性较小（男性和女性的OR分别为0.80；95%CI为0.64, 0.98和OR为0.70；95%CI为0.56, 0.86）。高膳食多酚总摄入量与女性的WC、血压、高脂蛋白胆固醇和甘油三酯呈负相关，与两性的空腹血糖也呈负相关。在各类多酚中，酚酸和芪类与代谢综合征显著相关；木脂素和芪类与WC相关；酚酸与血压和甘油三酯相关；黄酮类与空腹血糖相关。在多酚的特定亚类中，羟基肉桂酸、黄烷醇和二氢查耳酮发挥了最为重要的作用。
结论
膳食多酚的总量、各类别和亚类与代谢综合征及其某些组分呈负相关。
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