Morales Margaret, Asaban Brittany, Parsons Sarah, Chicella Michael
Department of Pharmacy (MM, BA, SP, MC) and Laboratory Services, Children's Hospital of The King's Daughters, Norfolk, VA.
Hampton University School of Pharmacy (MM), Hampton, VA.
J Pediatr Pharmacol Ther. 2024 Aug;29(4):399-403. doi: 10.5863/1551-6776-29.4.399. Epub 2024 Aug 13.
The purpose of this study was to determine if controlled substance waste management systems (CSWMS) demonstrate microbial growth, and therefore present a potential infection risk to pediatric hospital patients.
Twenty CSWMS, either Smart Sink or Pharma Lock systems, located in patient care areas were sampled. Twelve were located in critical care areas. Cultures were obtained by swabbing the drain grate with a sterile swab. Swabs were then transported to the microbiology lab for culture. Each sample was labeled with the location of the CSWMS and each system was photographed.
Of the CSWMS sampled, 50% demonstrated bacterial or fungal growth with a total of 15 microorganisms isolated, including 3 systems with , 2 with species, and 2 with -. Nine of the 15 microorganisms isolated were from systems in the pediatric intensive care unit (PICU) followed by 2 microorganisms in the neonatal intensive care unit (NICU). Of the 12 systems sampled in critical care areas, 8 (66%) had positive cultures. Of the 10 systems which demonstrated growth, 9 were Pharma Lock and 1 was Smart Sink.
Controlled substance waste management systems harbor potential pathogens and may serve as reservoirs of infectious agents in pediatric hospitals. Microbial growth was identified in more than half of sampled CSWMS located in critical care areas, where the most vulnerable patients are located. Based on this study, a cleaning procedure for CSWMS should be implemented. Further investigation on the relationship between CSWMS and nosocomial infections is warranted.
本研究旨在确定受控物质废物管理系统(CSWMS)是否会出现微生物生长,从而对儿科医院患者构成潜在感染风险。
对位于患者护理区域的20个CSWMS(智能水槽或药品锁系统)进行采样。其中12个位于重症监护区域。通过用无菌拭子擦拭排水篦子获取培养物。然后将拭子送往微生物实验室进行培养。每个样本都标注了CSWMS的位置,并对每个系统进行了拍照。
在采样的CSWMS中,50%显示出细菌或真菌生长,共分离出15种微生物,其中3个系统分离出 ,2个系统分离出 菌种,2个系统分离出 - 。分离出的15种微生物中有9种来自儿科重症监护病房(PICU)的系统,其次是新生儿重症监护病房(NICU)的2种微生物。在重症监护区域采样的12个系统中,8个(66%)培养结果呈阳性。在显示有生长的10个系统中,9个是药品锁系统,1个是智能水槽系统。
受控物质废物管理系统含有潜在病原体,可能成为儿科医院感染源的储存库。在位于最脆弱患者所在的重症监护区域的采样CSWMS中,超过一半发现有微生物生长。基于本研究,应实施CSWMS的清洁程序。有必要对CSWMS与医院感染之间的关系进行进一步调查。