Squillante Lucas, Mello Isys F, Ricco Luciano S, Minicucci Marcos F, Ukpong Aniekan Magnus, Seridonio Antonio C, Lagos-Monaco Roberto E, de Souza Mariano
São Paulo State University (Unesp), IGCE - Physics Department, Rio Claro - SP, Brazil.
Science Institute, University of Iceland, Dunhagi-3, IS-107, Reykjavik, Iceland.
Heliyon. 2024 Jul 17;10(15):e34622. doi: 10.1016/j.heliyon.2024.e34622. eCollection 2024 Aug 15.
Protein compartmentalization in the frame of a liquid-liquid phase separation is a key mechanism to optimize spatiotemporal control of biological systems. Such a compartmentalization process reduces the intrinsic noise in protein concentration due to stochasticity in gene expression. Employing Flory-Huggins solution theory, Avramov/Casalini's model, and the Grüneisen parameter, we unprecedentedly propose a cellular Griffiths-like phase (CGLP), which can impact its functionality and self-organization. The here-proposed CGLP is key ranging from the understanding of primary organisms' evolution to the treatment of diseases. Our findings pave the way for an alternative Biophysics approach to investigate coacervation processes.
在液-液相分离框架内的蛋白质区室化是优化生物系统时空控制的关键机制。这种区室化过程降低了由于基因表达的随机性导致的蛋白质浓度的内在噪声。利用弗洛里-哈金斯溶液理论、阿夫拉莫夫/卡萨利尼模型和格律内森参数，我们首次提出了一种细胞类格里菲斯相（CGLP），它会影响其功能和自组织。这里提出的CGLP对于理解原生生物的进化到疾病治疗都至关重要。我们的发现为研究凝聚过程的另一种生物物理学方法铺平了道路。
