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酪蛋白对可吸收合金的聚乳酸-酪蛋白涂层降解过程的影响。

Influence of casein on the degradation process of polylactide-casein coatings for resorbable alloys.

机构信息

Department of Engineering Materials and Biomaterials, Faculty of Mechanical Engineering, Silesian University of Technology, Gliwice, Poland.

Manufacturing Engineering Department, Technology Faculty, Karabuk University, Karabuk, Turkey.

出版信息

Sci Rep. 2024 Aug 15;14(1):18946. doi: 10.1038/s41598-024-69956-6.

DOI:10.1038/s41598-024-69956-6
PMID:39147799
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11327277/
Abstract

This study used the dip-coating method to develop a new biocompatible coating composed of polylactide (PLA) and casein for ZnMg1.2 wt% alloy implants. It evaluated its impact on the alloy's degradation in a simulated body fluid. After 168 h of immersion in Ringer's solution, surface morphology analysis showed that the PLA-casein coatings demonstrated uniform degradation, with the corrosion current density measured at 48 µA/cm. Contact angle measurements indicated that the average contact angles for the PLA-casein-coated samples were below 80°, signifying a hydrophilic nature that promotes cell adhesion. Fourier-transform infrared spectroscopy (FTIR) revealed no presence of lactic acid on PLA-casein coatings after immersion, in contrast to pure PLA coatings. Pull-off adhesion tests showed tensile strength values of 7.6 MPa for pure PLA coatings and 5 MPa for PLA-casein coatings. Electrochemical tests further supported the favorable corrosion resistance of the PLA-casein coatings, highlighting their potential to reduce tissue inflammation and improve the biocompatibility of ZnMg1.2 wt% alloy implants.

摘要

本研究采用浸涂法开发了一种由聚乳酸（PLA）和酪蛋白组成的新型生物相容性涂层，用于 ZnMg1.2wt%合金植入物。评估了其对合金在模拟体液中降解的影响。在 Ringer 溶液中浸泡 168 小时后，表面形貌分析表明 PLA-酪蛋白涂层表现出均匀的降解，腐蚀电流密度测量值为 48µA/cm。接触角测量表明 PLA-酪蛋白涂层样品的平均接触角低于 80°，表明其亲水性质有利于细胞附着。傅里叶变换红外光谱（FTIR）显示，与纯 PLA 涂层相比，PLA-酪蛋白涂层在浸泡后没有乳酸存在。剥离附着力测试表明，纯 PLA 涂层的拉伸强度值为 7.6MPa，PLA-酪蛋白涂层的拉伸强度值为 5MPa。电化学测试进一步证实了 PLA-酪蛋白涂层具有良好的耐腐蚀性，表明其有望降低组织炎症并提高 ZnMg1.2wt%合金植入物的生物相容性。

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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3798/11327277/7973362a7ff8/41598_2024_69956_Fig12_HTML.jpg

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