Department of Clinical Sciences, Swedish University of Agricultural Sciences, Uppsala, Sweden.
Department of Medical Biochemistry and Microbiology, Uppsala University, Uppsala, Sweden.
Acta Vet Scand. 2024 Aug 15;66(1):39. doi: 10.1186/s13028-024-00761-x.
The Nova Scotia Duck Tolling Retriever (NSDTR) has previously been highlighted as a breed at risk for developing immune mediated diseases and cancer. The immune response is of great importance for the development of neoplastic disease and a dysregulated immune response may predispose to cancer. Two of the commonly seen immune mediated diseases in NSDTRs are immune mediated rheumatic disease (IMRD), which bears similarities to systemic lupus erythematosus (SLE) affecting humans, and steroid-responsive meningitis-arteritis (SRMA), which is a non-infectious inflammation of the meninges and the leptomeningeal vessels. The aim of this survey study was to investigate the lifetime prevalence of immune mediated diseases and tumors among Swedish NSDTRs based on owners' information. The study design was cross-sectional. A questionnaire was sent to 4102 persons who owned or had previously owned a NSDTR. The questions concerned information about the dog and its overall health status as well as specific diseases.
The response rate was 30%, including 935 live NSDTRs, corresponding to approximately 20% of the current population registered in Sweden (n = 4564), and 177 dead dogs. The surveyed dogs were spread over different ages and sex and corresponded to the typical demographic profile of the general dog population. Of the 935 individuals that were alive, 28 dogs (3%) were reported as previously diagnosed with IMRD and 33 dogs (3.5%) were reported as previously diagnosed with SRMA, one dog was reported to have been diagnosed with both SRMA and IMRD. There were 129 dogs (14%) reported to have or have had a neoplasia of some kind. For the dead dogs (n = 177), almost 40% of the owners reported neoplasia as the main reason for death/euthanasia.
This study reports an estimated lifetime prevalence of IMRD and SRMA, in the studied population of Swedish NSDTRs, of 3.0 and 3.5% respectively. In this study, 14% of the living dogs (n = 935) were reported to have a neoplasia of some kind and almost 40% of the deceased dogs (n = 177) were euthanized due to neoplasia or suspicion of it.
新斯科舍诱鸭寻回猎犬（NSDTR）曾被认为是一种容易患免疫介导性疾病和癌症的品种。免疫反应对于肿瘤的发生非常重要，而失调的免疫反应可能会导致癌症。NSDTR 中常见的两种免疫介导性疾病是免疫介导性风湿病（IMRD），它与人类的系统性红斑狼疮（SLE）相似，以及类固醇反应性脑膜炎-动脉炎（SRMA），这是脑膜和软脑膜血管的非传染性炎症。本研究旨在基于主人的信息，调查瑞典 NSDTR 一生中免疫介导性疾病和肿瘤的患病率。该研究设计为横断面研究。向 4102 名拥有或曾经拥有 NSDTR 的人发送了一份问卷。问题涉及有关狗及其整体健康状况以及特定疾病的信息。
回复率为 30%，包括 935 只活 NSDTR，相当于瑞典当前登记的 NSDTR 总数（n=4564）的 20%，以及 177 只死狗。调查犬分布在不同的年龄和性别，与一般犬群的典型人口统计学特征相对应。在 935 只活的个体中，有 28 只（3%）被报告以前患有 IMRD，33 只（3.5%）被报告以前患有 SRMA，1 只狗被报告同时患有 SRMA 和 IMRD。有 129 只（14%）狗被报告患有某种肿瘤。对于死亡犬（n=177），近 40%的主人报告肿瘤是死亡/安乐死的主要原因。
本研究报告了在研究的瑞典 NSDTR 群体中，IMRD 和 SRMA 的终生患病率估计分别为 3.0%和 3.5%。在本研究中，报告有 14%的活狗（n=935）患有某种肿瘤，近 40%的死亡狗（n=177）因肿瘤或怀疑肿瘤而被安乐死。
