Crawford Christopher A, Polanka Brittanny M, Wu Wei, MacDonald Krysha L, Gupta Samir K, Stewart Jesse C
Indiana University-Purdue University Indianapolis, USA.
University of Alabama at Birmingham, USA.
J Health Psychol. 2025 Mar;30(3):590-596. doi: 10.1177/13591053241270630. Epub 2024 Aug 15.
We assess associations of somatic and cognitive/affective depressive symptom clusters with monocyte activation (soluble (s)CD14, sCD163), systemic inflammation (interleukin-6 (IL-6), high-sensitivity C-reactive protein (hsCRP)), and coagulation (D-dimer, fibrinogen) in people with HIV (PWH) on suppressive antiretroviral therapy with depression. Utilizing baseline data from a randomized controlled trial, we found no significant associations in linear regression models examining individual depressive symptom clusters; however, models examining both clusters simultaneously showed that the somatic cluster was positively associated with inflammation biomarkers, while the cognitive/affective cluster was negatively associated with inflammation and coagulation biomarkers (suggesting a cooperative suppression effect). Our findings indicate a differential association with depressive symptom clusters and biological mechanisms underlying cardiovascular disease (CVD) in HIV, which may be driven by unique components of each depressive symptom cluster. This line of research could identify subgroups of PWH with depression at elevated CVD risk needing early CVD prevention approaches. Supported by R01 HL126557.
我们评估了在接受抗逆转录病毒治疗且病情得到抑制但患有抑郁症的HIV感染者（PWH）中，躯体性和认知/情感性抑郁症状群与单核细胞活化（可溶性（s）CD14、sCD163）、全身炎症（白细胞介素-6（IL-6）、高敏C反应蛋白（hsCRP））及凝血（D-二聚体、纤维蛋白原）之间的关联。利用一项随机对照试验的基线数据，我们在检验单个抑郁症状群的线性回归模型中未发现显著关联；然而，同时检验两个症状群的模型显示，躯体性症状群与炎症生物标志物呈正相关，而认知/情感性症状群与炎症及凝血生物标志物呈负相关（提示协同抑制作用）。我们的研究结果表明，HIV感染者中抑郁症状群与心血管疾病（CVD）潜在生物学机制之间存在差异关联，这可能由每个抑郁症状群的独特成分驱动。这一系列研究可以识别出抑郁症患者中CVD风险升高且需要早期CVD预防措施的PWH亚组。由R01 HL126557资助。
