Blancas-Zugarazo Sugela Susana, Langley Elizabeth, Hidalgo-Miranda Alfredo
Cátedras CONAHCYT (Consejo Nacional de Humanidades Ciencia y Tecnología) - Laboratorio de Genómica del Cáncer, Instituto Nacional de Medicina Genómica (INMEGEN), Mexico City, Mexico.
Laboratorio de Cáncer Hormono Regulado, Instituto Nacional de Cancerología (INCAN), Mexico City, Mexico.
Front Oncol. 2024 Aug 1;14:1419808. doi: 10.3389/fonc.2024.1419808. eCollection 2024.
Breast cancer is the most common cancer in women and the leading cause of female deaths by cancer in the world worldwide. Hence, understanding the molecular mechanisms associated with breast cancer development and progression, including drug resistance and breast cancer metastasis, is essential for achieving the best management of breast cancer patients. Cancer-related long noncoding RNAs have been shown to be involved in the regulation of each stage of breast cancer progression. Additionally, exosomes are extracellular microvesicles that are central to intercellular communication and play an important role in tumorigenesis. Exosomes can be released from primary tumor cells into the bloodstream and transmit cellular signals to distant body sites. In this work, we review the findings regarding the cellular mechanisms regulated by exosomal lncRNAs that are essentials to chemoresistance development and metastasis of breast cancer. Likewise, we evaluate the outcomes of the potential clinical use of exosomal lncRNAs as breast cancer biomarkers to achieve personalized management of the patients. This finding highlights the importance of transcriptomic analysis of exosomal lncRNAs to understand the breast cancer tumorigenesis as well as to improve the clinical tests available for this disease.
乳腺癌是女性中最常见的癌症，也是全球女性癌症死亡的主要原因。因此，了解与乳腺癌发生和发展相关的分子机制，包括耐药性和乳腺癌转移，对于实现乳腺癌患者的最佳管理至关重要。癌症相关的长链非编码RNA已被证明参与乳腺癌进展各个阶段的调控。此外，外泌体是细胞外微囊泡，是细胞间通讯的核心，在肿瘤发生中起重要作用。外泌体可从原发性肿瘤细胞释放到血液中，并将细胞信号传递到身体远处部位。在这项工作中，我们综述了关于外泌体长链非编码RNA调控的细胞机制的研究结果，这些机制是乳腺癌化疗耐药性发展和转移的关键。同样，我们评估了外泌体长链非编码RNA作为乳腺癌生物标志物的潜在临床应用结果，以实现患者的个性化管理。这一发现突出了外泌体长链非编码RNA转录组分析对于理解乳腺癌肿瘤发生以及改进该疾病现有临床试验的重要性。
