基于修饰丝网印刷电极的左旋多巴作为帕金森治疗药物的高效电催化氧化

Highly efficient electrocatalytic oxidation of levodopa as a Parkinson therapeutic drug based on modified screen-printed electrode.

作者信息

Wang Tan, Jafar Nadhir N A, Al-Rihaymee Afrah Majeed Ahmed, Alhameedi Dheyaa Yahaia, Rasen Fadhil A, Hashim Furqan S, Hussein Talib Kh, Ramadan Montather F, Alasedi Kasim Kadhim, Suliman Muath, Alawadi Ahmed Hussien

机构信息

Three Gorges University, College of Basie Medical Scienees, 443002, China.

Al-Zahraa Center for Medical and Pharmaceutical Research Sciences (ZCMRS), Al-Zahraa University for Women, Karbala, 56001, Iraq.

出版信息

Heliyon. 2024 Jul 21;10(14):e34689. doi: 10.1016/j.heliyon.2024.e34689. eCollection 2024 Jul 30.

The current study presents the creation of a straightforward and sensitive sensor based on ZnO/CoO nanocomposite modified screen-printed electrode (ZnO/CoONC/SPE) for levodopa determination. At ZnO/CoONC/SPE, an oxidative peak for levodopa solution in pH 6.0 phosphate buffer solution (PBS) were seen that were both more resolved and more enhanced. Levodopa was measured using differential pulse voltammetry (DPV), which showed an excellent linear range (0.001-800.0 μM) and detection limit (0.81 nM). The presence of interference did not affect the electrochemical response of levodopa at ZnO/CoONC/SPE, demonstrating high selectivity. Levodopa in a real samples have been successfully detected using the manufactured sensor.