杂芳烃与未活化的C(sp³)-H化合物的有机光电催化C(sp²)-H烷基化反应。
Organophotoelectrocatalytic C(sp)-H alkylation of heteroarenes with unactivated C(sp)-H compounds.
作者信息
Wan Qinhui, Wu Xia-Die, Hou Zhong-Wei, Ma Yongmin, Wang Lei
机构信息
Advanced Research Institute and School of Pharmaceutical Sciences, Taizhou University, Jiaojiang, Zhejiang, 318000, P. R. China.
College of Material Chemistry and Chemical Engineering, Key Laboratory of Organosilicon Chemistry and Material Technology, Ministry of Education, Hangzhou Normal University, Hangzhou, 311121, Zhejiang, P. R. China.
出版信息
Chem Commun (Camb). 2024 May 21;60(42):5502-5505. doi: 10.1039/d4cc01335b.
An organophotoelectrocatalytic method for the C(sp)-H alkylation of heteroarenes with unactivated C(sp)-H compounds through dehydrogenation cross-coupling has been developed. The C(sp)-H alkylation combines organic catalysis, photochemistry and electrochemistry, avoiding the need for external metal-reagents, HAT-reagents, and oxidants. This protocol exhibits good substrate tolerance and functional group compatibility, providing a straightforward and powerful pathway to access a variety of alkylated heteroarenes under green conditions.
已开发出一种有机光催化电催化方法，用于通过脱氢交叉偶联使杂芳烃与未活化的C(sp)-H化合物进行C(sp)-H烷基化反应。该C(sp)-H烷基化反应结合了有机催化、光化学和电化学，无需外部金属试剂、氢原子转移（HAT）试剂和氧化剂。该方法具有良好的底物耐受性和官能团兼容性，为在绿色条件下获得各种烷基化杂芳烃提供了一条直接且强大的途径。
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