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在TREM2心脏巨噬细胞中进行治疗性基因沉默可抑制心房颤动。

Therapeutic silencing in TREM2 cardiac macrophages suppresses atrial fibrillation.

作者信息

Momin Noor, Pabel Steffen, Rudra Arnab, Kumowski Nina, Lee I-Hsiu, Mentkowski Kyle, Yamazoe Masahiro, Stengel Laura, Muse Charlotte G, Seung Hana, Paccalet Alexandre, Gonzalez-Correa Cristina, Jacobs Emily B, Grune Jana, Schloss Maximilian J, Sossalla Samuel, Wojtkiewicz Gregory, Iwamoto Yoshiko, McMullen Patrick, Mitchell Richard N, Ellinor Patrick T, Anderson Daniel G, Naxerova Kamila, Nahrendorf Matthias, Hulsmans Maarten

机构信息

Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.

Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.

出版信息

bioRxiv. 2024 Aug 10:2024.08.10.607461. doi: 10.1101/2024.08.10.607461.

DOI:10.1101/2024.08.10.607461
PMID:39149373
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11326243/
Abstract

Atrial fibrillation (AFib) and the risk of its lethal complications are propelled by fibrosis, which induces electrical heterogeneity and gives rise to reentry circuits. Atrial TREM2 macrophages secrete osteopontin (encoded by ), a matricellular signaling protein that engenders fibrosis and AFib. Here we show that silencing in TREM2 cardiac macrophages with an antibody-siRNA conjugate reduces atrial fibrosis and suppresses AFib in mice, thus offering a new immunotherapy for the most common arrhythmia.

摘要

心房颤动（AFib）及其致命并发症的风险由纤维化推动，纤维化会导致电不均一性并产生折返环路。心房中的TREM2巨噬细胞分泌骨桥蛋白（由[具体基因]编码），这是一种促纤维化和AFib的基质细胞信号蛋白。在这里，我们表明，用抗体-小干扰RNA偶联物沉默TREM2心脏巨噬细胞中的[具体基因]可减少小鼠心房纤维化并抑制AFib，从而为这种最常见的心律失常提供了一种新的免疫疗法。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/821d/11326243/e5e47d102dc3/nihpp-2024.08.10.607461v1-f0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/821d/11326243/10634ba8093f/nihpp-2024.08.10.607461v1-f0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/821d/11326243/07de1aff530c/nihpp-2024.08.10.607461v1-f0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/821d/11326243/bbd88bdb2760/nihpp-2024.08.10.607461v1-f0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/821d/11326243/55b667818d9c/nihpp-2024.08.10.607461v1-f0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/821d/11326243/d574f85f8716/nihpp-2024.08.10.607461v1-f0007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/821d/11326243/3e4cb1e69597/nihpp-2024.08.10.607461v1-f0008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/821d/11326243/bd166362ca28/nihpp-2024.08.10.607461v1-f0009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/821d/11326243/1ea5a5296677/nihpp-2024.08.10.607461v1-f0010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/821d/11326243/50c41502a0c9/nihpp-2024.08.10.607461v1-f0011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/821d/11326243/64b4cd00ce31/nihpp-2024.08.10.607461v1-f0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/821d/11326243/e5e47d102dc3/nihpp-2024.08.10.607461v1-f0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/821d/11326243/10634ba8093f/nihpp-2024.08.10.607461v1-f0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/821d/11326243/07de1aff530c/nihpp-2024.08.10.607461v1-f0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/821d/11326243/bbd88bdb2760/nihpp-2024.08.10.607461v1-f0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/821d/11326243/55b667818d9c/nihpp-2024.08.10.607461v1-f0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/821d/11326243/d574f85f8716/nihpp-2024.08.10.607461v1-f0007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/821d/11326243/3e4cb1e69597/nihpp-2024.08.10.607461v1-f0008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/821d/11326243/bd166362ca28/nihpp-2024.08.10.607461v1-f0009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/821d/11326243/1ea5a5296677/nihpp-2024.08.10.607461v1-f0010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/821d/11326243/50c41502a0c9/nihpp-2024.08.10.607461v1-f0011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/821d/11326243/64b4cd00ce31/nihpp-2024.08.10.607461v1-f0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/821d/11326243/e5e47d102dc3/nihpp-2024.08.10.607461v1-f0002.jpg

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2
Mechanistic Pharmacokinetics and Pharmacodynamics of GalNAc-siRNA: Translational Model Involving Competitive Receptor-Mediated Disposition and RISC-Dependent Gene Silencing Applied to Givosiran.GalNAc-siRNA 的作用机制药代动力学和药效动力学：涉及竞争性受体介导处置和 RISC 依赖性基因沉默的转化模型，应用于 Givosiran。
J Pharm Sci. 2024 Jan;113(1):176-190. doi: 10.1016/j.xphs.2023.10.026. Epub 2023 Oct 21.
3
Balancing safety and efficacy: tuning the biodistribution and pharmacokinetics of cytokine immunotherapies.
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Curr Opin Biotechnol. 2023 Dec;84:102994. doi: 10.1016/j.copbio.2023.102994. Epub 2023 Oct 6.
4
Unsupervised removal of systematic background noise from droplet-based single-cell experiments using CellBender.基于 CellBender 的无监督去除液滴式单细胞实验系统背景噪声。
Nat Methods. 2023 Sep;20(9):1323-1335. doi: 10.1038/s41592-023-01943-7. Epub 2023 Aug 7.
5
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6
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