Department of Public Health and Infectious Diseases, Microbiology Section, "Sapienza" University of Rome, Rome, Italy.
Department of Maternal and Child Health and Urology, "Sapienza" University of Rome, Rome, Italy.
Arch Gynecol Obstet. 2024 Oct;310(4):2141-2151. doi: 10.1007/s00404-024-07631-x. Epub 2024 Aug 16.
This cross-sectional study aims to assess the interplay between the vaginal microbiota and endometriosis.
123 consecutive Italian fertile women, aged between 20 and 40 years old, were enrolled during a routine gynecological consultation; 24 were diagnosed with endometriosis and 99 did not complain of any gynecological disease. All women underwent a vaginal swab for the evaluation of the composition and diversity of vaginal microbiota by means of 16 s rDNA metagenomic sequencing.
Compared to women with no gynecological disease, the vaginal microbiota in women with endometriosis showed a similar abundance of Lactobacillus spp.; however, a statistically significant lower abundance in the genera Pseudomonas (p < 0.01), Bifidobacterium (p < 0.05), Novispirillum (p < 0.0000001) and Sphingomonas (p < 0.0000001), and a statistically significant increase in the abundance of the genera Escherichia (p < 0.00001), Megasphaera (p < 0.00001), and Sneathia (p < 0.0001) were observed.
There is a complex interplay between vaginal microbiota composition and endometriosis, showing a distinct microbial signature in the bacterial genera usually found in dysbiosis.
本横断面研究旨在评估阴道微生物群与子宫内膜异位症之间的相互作用。
在常规妇科就诊期间，招募了 123 名年龄在 20 至 40 岁之间的连续意大利生育期妇女；24 名被诊断为子宫内膜异位症，99 名没有妇科疾病。所有女性均接受阴道拭子检查，通过 16s rDNA 宏基因组测序评估阴道微生物群的组成和多样性。
与无妇科疾病的女性相比，子宫内膜异位症女性的阴道微生物群中乳杆菌属的丰度相似；然而，假单胞菌属（p < 0.01）、双歧杆菌属（p < 0.05）、新鞘氨醇单胞菌属（p < 0.0000001）和鞘氨醇单胞菌属（p < 0.0000001）的丰度显著降低，而大肠杆菌属（p < 0.00001）、巨球形菌属（p < 0.00001）和 Sneathia 菌属（p < 0.0001）的丰度显著增加。
阴道微生物群组成与子宫内膜异位症之间存在复杂的相互作用，在通常与失调相关的细菌属中表现出独特的微生物特征。
