Department of Obstetrics and Gynecology, West China Second University Hospital, Sichuan University, Chengdu, China.
Reproductive Endocrinology and Regulation Laboratory, West China Second University Hospital, Sichuan University, Chengdu, China.
Dis Markers. 2022 Jul 25;2022:3767373. doi: 10.1155/2022/3767373. eCollection 2022.
To systematically evaluate the differences in intestinal flora before and after menopause. To provide a possible mechanism for perimenopausal syndrome and provide a basis for probiotics as adjuvant therapy.
MEDLINE, EMBASE, Web of Science, Cochrane Central Register of Controlled Trials (CENTRAL), CNKI, Wanfang, and VIP databases were searched. The included studies were case-control studies.
Three case-control studies were included, with a total of 156 people. At the phylum level, there were no differences between premenopausal and postmenopausal women. At the genus level, the relative abundances of A. odoratum and B. cholerae were higher in postmenopausal women than in premenopausal women, with no differences among other genera. The Shannon diversity index increased after menopause, but no differences were found. Only one study found a positive association of estradiol with Gammaproteobacteria and Myxococcales and a negative association with Prevotellaceae.
On the basis of previous studies, it was found that there was no significant difference at the phylum level between postmenopausal women and premenopausal women, but Odoribacter and Bilophila increased at the genus level in postmenopausal women. The class of Gammaproteobacteria may be positively correlated with estradiol. Limited by the number of included studies, more high-quality clinical studies are needed for validation.
系统评价绝经前后肠道菌群的差异。为围绝经期综合征提供可能的机制，并为益生菌作为辅助治疗提供依据。
检索 MEDLINE、EMBASE、Web of Science、Cochrane 中央对照试验注册库（CENTRAL）、中国知网（CNKI）、万方和维普数据库。纳入的研究为病例对照研究。
共纳入 3 项病例对照研究，共 156 人。在门水平上，绝经前后女性肠道菌群无差异。在属水平上，绝经后女性肠道中产丁酸弧菌和霍乱弧菌的相对丰度高于绝经前女性，其他属无差异。绝经后 Shannon 多样性指数增加，但无差异。仅有 1 项研究发现雌二醇与γ-变形菌纲和粘球菌目呈正相关，与普雷沃氏菌科呈负相关。
基于既往研究，发现绝经后女性与绝经前女性在门水平上无显著差异，但在属水平上绝经后女性中产丁酸弧菌和霍乱弧菌的相对丰度增加。γ-变形菌纲可能与雌二醇呈正相关。受纳入研究数量的限制，需要更多高质量的临床研究进行验证。
