Li Daiwei, Wang Nanchao, Li Mucong, Mishra Arpit, Tang Yuqi, Vu Tri, Xiang Gaoming, Chen Junqin, Lipkin Michael, Zhong Pei, Yao Junjie
IEEE Trans Ultrason Ferroelectr Freq Control. 2024 Dec;71(12: Breaking the Resolution Barrier in Ultrasound):1690-1700. doi: 10.1109/TUFFC.2024.3443781. Epub 2025 Jan 8.
Kidney stone disease is a major public health issue. By breaking stones with repeated laser irradiation, laser lithotripsy (LL) has become the main treatment for kidney stone disease. Laser-induced cavitation is closely associated with stone damage in LL. Monitoring the cavitation activities during LL is thus crucial to optimizing the stone damage and maximizing LL efficiency. In this study, we have developed 3-D super-resolution passive cavitation mapping (3D-SRPCM), in which the cavitation bubble positions can be localized with an accuracy of m, which is 1/10th of the acoustic diffraction limit. Moreover, the 3D-SRPCM reconstruction speed has been improved by 300 times by adopting a GPU-based sparse-matrix beamforming approach. Using 3D-SRPCM, we studied LL-induced cavitation activities on BegoStones, both in free space of water and confined space of a kidney phantom. The dose-dependent analysis provided by 3D-SRPCM revealed that accumulated impact pressure on the stone surface has the highest correlation with the stone damage. By providing high-resolution cavitation mapping during LL treatment, we expect that 3D-SRPCM may become a powerful tool to improve the clinical LL efficiency and patient outcome.
肾结石病是一个重大的公共卫生问题。通过重复激光照射破碎结石，激光碎石术（LL）已成为治疗肾结石病的主要方法。激光诱导的空化与激光碎石术中的结石损伤密切相关。因此，在激光碎石术中监测空化活动对于优化结石损伤和最大化激光碎石术效率至关重要。在本研究中，我们开发了三维超分辨率被动空化映射（3D-SRPCM），其中空化气泡位置的定位精度可达微米级，这是声衍射极限的十分之一。此外，通过采用基于图形处理器（GPU）的稀疏矩阵波束形成方法，三维超分辨率被动空化映射的重建速度提高了300倍。利用3D-SRPCM，我们研究了在水的自由空间和肾脏模型的受限空间中，激光碎石术对Bego结石诱导的空化活动。3D-SRPCM提供的剂量依赖性分析表明，结石表面的累积冲击压力与结石损伤的相关性最高。通过在激光碎石术治疗期间提供高分辨率的空化映射，我们期望3D-SRPCM可能成为提高临床激光碎石术效率和患者治疗效果的有力工具。
