R&D, SUNSTAR Inc., Takatsuki, Osaka, Japan.
Midori Health Center, Nagoya, Aichi, Japan.
PLoS One. 2024 Aug 16;19(8):e0309012. doi: 10.1371/journal.pone.0309012. eCollection 2024.
Dental caries and periodontal disease are typical oral diseases frequently observed in patients with renal diseases. Tooth loss is an outcome of dental caries and periodontal disease, and the number of existing teeth is an indicator of oral health status. However, the association between the number of existing teeth and end-stage kidney disease (ESKD) has not been investigated in detail. This study aimed to investigate the association between oral health status, expressed by the number of existing teeth, and ESKD. We analyzed data from the second survey of the Longitudinal Evaluation of Multi-phasic, Odontological, and Nutritional Associations in Dentists, a cohort study conducted among members of the Japan Dental Association. From August 2016 to July 2017, self-administered questionnaires were mailed to 16,128 male dentists and 8,722 responded. Among them, 7,479 men with complete data on age, number of existing teeth, and ESKD were included in the analysis. Multivariate logistic regression analysis was conducted, with ESKD as the dependent variable and the number of existing teeth (≥23 teeth and <23 teeth) as the independent variable. Subgroup analysis by age (<65 years and ≥65 years) was also conducted. The <23 teeth group had a significantly higher rate of ESKD than did the ≥23 teeth group. After adjusting for age, body mass index, smoking habits, hypertension, and diabetes mellitus, there was no significant association between having <23 teeth and ESKD in all participants. However, the subgroup analysis revealed a significant association after adjustment for covariates in participants aged <65 years but not in those aged ≥65 years. In conclusion, having <23 teeth was associated with the risk of requiring maintenance dialysis therapy among Japanese men aged <65 years. Therefore, tooth loss may be associated with renal function decline.
龋齿和牙周病是肾病患者中常见的口腔疾病。牙齿缺失是龋齿和牙周病的结果，而现存牙齿的数量是口腔健康状况的一个指标。然而，现存牙齿数量与终末期肾病（ESKD）之间的关系尚未得到详细研究。本研究旨在探讨口腔健康状况，用现存牙齿数量来表示，与 ESKD 之间的关系。我们分析了日本牙科协会成员进行的一项队列研究——多相、口腔和营养关联的纵向评估的第二次调查的数据。2016 年 8 月至 2017 年 7 月，向 16128 名男性牙医和 8722 名牙医邮寄了自填式问卷。其中，7479 名男性牙医年龄、现存牙齿数量和 ESKD 数据完整，纳入分析。采用多变量逻辑回归分析，以 ESKD 为因变量，现存牙齿数量（≥23 颗和＜23 颗）为自变量。还按年龄（＜65 岁和≥65 岁）进行了亚组分析。与≥23 颗牙齿组相比，＜23 颗牙齿组的 ESKD 发生率明显更高。在调整年龄、体重指数、吸烟习惯、高血压和糖尿病后，所有参与者中，＜23 颗牙齿与 ESKD 之间没有显著关联。然而，亚组分析显示，在调整年龄＜65 岁参与者的协变量后，两者之间存在显著关联，但在年龄≥65 岁的参与者中没有显著关联。总之，年龄＜65 岁的日本男性中，＜23 颗牙齿与需要维持透析治疗的风险相关。因此，牙齿缺失可能与肾功能下降有关。
