Mental Health Center and West China Biomedical Big Data Center, West China Hospital, Sichuan University, Guo Xue Lane 37, Chengdu, China.
Med-X Center for Informatics, Sichuan University, Chengdu, China.
BMC Med. 2024 Sep 4;22(1):359. doi: 10.1186/s12916-024-03578-7.
Psychological and trauma-related factors are associated with many diseases and mortality. However, a comprehensive assessment of the association between psycho-trauma exposures and aging acceleration is currently lacking.
Using data from 332,359 UK Biobank participants, we calculated biological aging acceleration, indexed by the presence of leukocyte telomere length (LTL) deviation (i.e., the difference between genetically determined and observed LTL > 0). The acceleration of facial aging (i.e., looking older than the chronological age) was assessed using a self-report question. Then, we estimated the associations of each psycho-trauma factor with biological and facial aging acceleration, using logistic regression models adjusted for multiple important covariates. Furthermore, restricted to 99,180 participants with complete psychological and trauma-related data, we identified clusters of individuals with distinct psycho-trauma patterns using the latent class analysis method and assessed their associations with aging acceleration using similar models.
We observed most of the studied psycho-trauma factors were associated with biological and facial aging acceleration. Compared to the "Absence of trauma and psychopathology" cluster, the "adverse childhood experiences (ACEs) with psychopathology" cluster showed strong associations with those aging measurements (odds ratio [OR] = 1.13 [1.05 - 1.23] for biological and 1.52 [1.18 - 1.95] for facial aging acceleration), while no such association was observed for the "ACEs without psychopathology" cluster (1.04 [0.99 - 1.09] and 1.02 [0.84 - 1.24].
Our study demonstrated significant associations of psycho-trauma factors with both biological and facial aging acceleration. The differential aging consequences observed among ACEs exposed individuals with and without psychopathology prompt interventions aimed to improve individuals' psychological resilience to prevent aging acceleration.
心理和创伤相关因素与许多疾病和死亡率有关。然而，目前缺乏对心理创伤暴露与衰老加速之间关联的综合评估。
使用来自 332359 名英国生物库参与者的数据，我们计算了生物衰老加速，由白细胞端粒长度（LTL）偏差的存在来表示（即，遗传决定的和观察到的 LTL 之间的差异>0）。使用自我报告问题评估面部衰老的加速（即看起来比实际年龄老）。然后，我们使用逻辑回归模型调整了多个重要协变量，估计了每个心理创伤因素与生物和面部衰老加速的关联。此外，在 99180 名具有完整心理和创伤相关数据的参与者中，我们使用潜在类别分析方法确定了具有不同心理创伤模式的个体聚类，并使用类似的模型评估了它们与衰老加速的关联。
我们观察到大多数研究的心理创伤因素与生物和面部衰老加速有关。与“无创伤和精神病理学”聚类相比，“不良儿童经历（ACEs）伴精神病理学”聚类与这些衰老测量值呈强关联（生物衰老加速的比值比[OR] = 1.13[1.05-1.23]，面部衰老加速的 1.52[1.18-1.95]），而“无精神病理学的 ACEs”聚类则没有观察到这种关联（生物衰老加速的 1.04[0.99-1.09]和面部衰老加速的 1.02[0.84-1.24]）。
我们的研究表明，心理创伤因素与生物和面部衰老加速均显著相关。在暴露于 ACEs 的个体中，有和没有精神病理学的个体之间观察到的不同衰老后果提示采取干预措施，以提高个体的心理适应能力，防止衰老加速。
