Institute of Marine Biochemistry, Vietnam Academy of Science and Technology (VAST), Cau Giay, Hanoi, Vietnam.
Graduate University of Science and Technology, Vietnam Academy of Science and Technology, Cau Giay, Hanoi, Vietnam.
Biosci Biotechnol Biochem. 2024 Oct 22;88(11):1254-1260. doi: 10.1093/bbb/zbae113.
One new compound, methyl 3-((1-((2-carbamoylphenyl)amino)-1-oxopropan-2-yl)amino)-3-oxopropanoate (1), along with 9 known secondary metabolites (2-10) were isolated and elucidated chemical structures from the methanol extract of the marine-derived fungus Penicillium chrysogenum VH17. Subsequent bioassays showed the antimicrobial and cytotoxic potential of the isolated compounds. All compounds 1-10 displayed antimicrobial effects against at least one tested reference microorganism with MIC values ranging from 32 to 256 µg mL-1. Furthermore, compound 4 exhibited significant cytotoxicity against all tested cell lines, HepG2, A549, and MCF7 with IC50 values of 29.43 ± 1.37, 33.02 ± 1.53, and 36.72 ± 1.88 µM, respectively, whereas compound 3 exhibited weak cytotoxicity against MCF7 and HepG2 cell lines with IC50 values of 87.17 ± 6.31 and 97.32 ± 5.66 µM, respectively.
从海洋来源真菌青霉 VH17 的甲醇提取物中分离得到一种新的化合物，甲基 3-((1-((2-氨甲酰基苯基)氨基)-1-氧代丙-2-基)氨基)-3-氧代丙酸盐（1），以及 9 种已知的次级代谢产物（2-10）。随后的生物测定表明，分离得到的化合物具有抗菌和细胞毒性潜力。所有化合物 1-10 对至少一种测试的参考微生物均显示出抗菌作用，MIC 值范围为 32 至 256 µg mL-1。此外，化合物 4 对所有测试的细胞系 HepG2、A549 和 MCF7 均表现出显著的细胞毒性，IC50 值分别为 29.43 ± 1.37、33.02 ± 1.53 和 36.72 ± 1.88 µM，而化合物 3 对 MCF7 和 HepG2 细胞系的细胞毒性较弱，IC50 值分别为 87.17 ± 6.31 和 97.32 ± 5.66 µM。
