Girotti A W
J Free Radic Biol Med. 1985;1(2):87-95. doi: 10.1016/0748-5514(85)90011-x.
This article provides an overview of how peroxidation of unsaturated lipids takes place and how it can be measured. Several different aspects of free-radical-mediated lipid peroxidation are discussed, including: the catalytic role of chelated iron and other redox metal ions; induction by reducing agents such as superoxide, ascorbate, and xenobiotic free radicals; suppression by antioxidant chemicals and enzymes; and how peroxidation that depends on pre-existing hydroperoxides (lipid hydroperoxide-dependent initiation of lipid peroxidation) can be distinguished from that which does not (lipid hydroperoxide-independent initiation of lipid peroxidation). Attention is also given to non-radical, singlet oxygen-driven peroxidation and how this can be resolved from radical-driven processes.
本文概述了不饱和脂质过氧化作用的发生过程及其测定方法。讨论了自由基介导的脂质过氧化作用的几个不同方面，包括：螯合铁和其他氧化还原金属离子的催化作用；超氧化物、抗坏血酸和外源性自由基等还原剂的诱导作用；抗氧化化学物质和酶的抑制作用；以及如何区分依赖于预先存在的氢过氧化物的过氧化作用（脂质过氧化的脂质氢过氧化物依赖性引发）和不依赖于氢过氧化物的过氧化作用（脂质过氧化的脂质氢过氧化物非依赖性引发）。还关注了非自由基、单线态氧驱动的过氧化作用以及如何将其与自由基驱动的过程区分开来。
