Service of Clinical Microbiology, CHU UCL Namur and Université Catholique de Louvain, Rue Gaston Thérasse, 1, Godinne, Yvoir 5530 , Belgium.
Service of Clinical Microbiology, CHU UCL Namur and Université Catholique de Louvain, Rue Gaston Thérasse, 1, Godinne, Yvoir 5530 , Belgium.
Diagn Microbiol Infect Dis. 2024 Nov;110(3):116493. doi: 10.1016/j.diagmicrobio.2024.116493. Epub 2024 Aug 13.
Candidemia, predominantly caused by C. albicans, poses a significant threat in hospitals. Yet, non-albicans candidemia (NAC) and antifungal resistance are increasing concerns. This retrospective study at CHU UCL Namur Mont-Godinne, a Belgian university hospital, from January 2013 to February 2023, analyzed 148 candidemia cases. The mean annual incidence was 0.94 per 1000 admissions, with a notable surge in C. albicans cases in 2020, possibly due to COVID-19. Candidemia was most prevalent in the ICU (48 %), with C. albicans (57.1 %) and C. glabrata (18.4 %) being the predominant species and a 30-day mortality rate of 38 %. NAC was significantly higher in the hematology unit (81 %). Notably, no echinocandin resistance was observed, while fluconazoleresistance remained stable at 10 %. NAC was associated with azole resistance. This study provides a decade-long overview of candidemia at CHU UCL Namur Mont-Godinne, offering valuable insights into its epidemiology and clinical characteristics in Belgian hospital settings.
念珠菌血症主要由白念珠菌引起，在医院中构成重大威胁。然而，非白念珠菌性念珠菌血症（NAC）和抗真菌药物耐药性日益令人担忧。本研究回顾性分析了 2013 年 1 月至 2023 年 2 月期间在比利时大学附属医院 CHU UCL Namur Mont-Godinne 的 148 例念珠菌血症病例。平均每年发病率为每 1000 例住院患者 0.94 例，2020 年白念珠菌病例显著增加，可能与 COVID-19 有关。念珠菌血症最常见于 ICU（48%），主要病原体为白念珠菌（57.1%）和光滑念珠菌（18.4%），30 天死亡率为 38%。血液科念珠菌血症发病率显著更高（81%）。值得注意的是，未观察到棘白菌素耐药，氟康唑耐药率保持稳定在 10%。NAC 与唑类耐药相关。本研究提供了 CHU UCL Namur Mont-Godinne 十年来念珠菌血症的概述，为比利时医院环境中念珠菌血症的流行病学和临床特征提供了有价值的见解。
