Lagunas-Rangel Francisco Alejandro
Department of Surgical Sciences, Uppsala University, Uppsala, Sweden.
NPJ Aging. 2024 Aug 17;10(1):38. doi: 10.1038/s41514-024-00166-0.
Heterochronic parabiosis consists of surgically connecting the circulatory systems of a young and an old animal. This technique serves as a model to study circulating factors that accelerate aging in young organisms exposed to old blood or induce rejuvenation in old organisms exposed to young blood. Despite the promising results, the exact cellular and molecular mechanisms remain unclear, so this study aims to explore and elucidate them in more detail.
异时共生包括通过手术连接幼龄动物和老龄动物的循环系统。该技术作为一种模型，用于研究在接触老龄血液的幼龄生物体中加速衰老或在接触幼龄血液的老龄生物体中诱导年轻化的循环因子。尽管取得了令人鼓舞的结果，但确切的细胞和分子机制仍不清楚，因此本研究旨在更详细地探索和阐明这些机制。
