Department of Clinical Laboratory, Affiliated Jinhua Hospital, Zhejiang University School of Medicine, Jinhua, Zhejiang 321000, P.R. China.
Department of Clinical Medicine, Institute of Translational Medicine, Medical College, Yangzhou University, Yangzhou, Jiangsu 225000, P.R. China.
Mol Med Rep. 2024 Oct;30(4). doi: 10.3892/mmr.2024.13309. Epub 2024 Aug 19.
Glycolysis occurs in all living organisms as a form of energy supply. Pyruvate kinase M2 (PKM2) is one of the rate‑limiting enzymes in the glycolytic process. PKM2 is considered to serve an important role in several terminal diseases, including sepsis. However, to the best of our knowledge, the specific mechanistic role of PKM2 in sepsis remains to be systematically summarised. Therefore, the present review aims to summarise the roles of PKM2 in sepsis progression. In addition, potential treatment strategies for patients with sepsis are discussed. The present review hopes to lay the groundwork for studying the role of PKM2 and developing therapeutic strategies against metabolic disorders that occur during sepsis.
糖酵解作为一种能量供应形式存在于所有生物体中。丙酮酸激酶 M2（PKM2）是糖酵解过程中的限速酶之一。PKM2 被认为在包括脓毒症在内的几种终末期疾病中发挥重要作用。然而，据我们所知，PKM2 在脓毒症中的具体作用机制仍有待系统总结。因此，本综述旨在总结 PKM2 在脓毒症进展中的作用。此外，还讨论了针对脓毒症患者的潜在治疗策略。本综述希望为研究 PKM2 的作用以及开发针对脓毒症期间发生的代谢紊乱的治疗策略奠定基础。
