山奈酚摄入对身体活动和睡眠质量的影响：一项双盲、安慰剂对照、随机交叉试验。
Effect of kaempferol ingestion on physical activity and sleep quality: a double-blind, placebo-controlled, randomized, crossover trial.
作者信息
Ikeda Yasutaka, Gotoh-Katoh Aina, Okada Shinpei, Handa Shuichi, Sato Teruyuki, Mizokami Tsubasa, Saito Bungo
机构信息
Otsu Nutraceuticals Research Institute, Otsuka Pharmaceutical Co. Ltd., Otsu, Japan.
Physical Education and Medicine Research Foundation, Tomi, Japan.
出版信息
Front Nutr. 2024 Aug 2;11:1386389. doi: 10.3389/fnut.2024.1386389. eCollection 2024.
BACKGROUND
Kaempferol (KMP), a flavonoid in edible plants, exhibits diverse pharmacological effects. Growing body of evidence associates extended lifespan with physical activity (PA) and sleep, but KMP's impact on these behaviors is unclear. This double-blind, placebo-controlled, crossover trial assessed KMP's effects on PA and sleep.
METHODS
A total of 33 city workers (17 males and 16 females) participated in this study. They were randomly assigned to take either 10 mg of KMP or placebo for 2 weeks in the order allocated, with a 7-day washout period in between. All participants wore an accelerometer-based wearable device (Fitbit Charge 4), which monitored daily PA, heart rate (HR), and HR variability during sleep.
RESULTS
The duration of wearing the device was 23.73 ± 0.04 h/day. HR decreased in each PA level, and the mean daily step count and distance covered increased significantly during KMP intake compared to placebo. The outing rate, number of trips, number of recreational activities, and time spent in recreation on weekends increased. Sleep quality improved following KMP intake. The decrease in HR and increase in RMSSD may be important in mediating the effects of these KMPs.
CONCLUSION
KMP leads to behavioral changes that subsequently improve sleep quality and potentially improve long-term quality of life.
CLINICAL TRIAL REGISTRATION
https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000048447, UMIN000042438.
背景
山奈酚（KMP）是可食用植物中的一种黄酮类化合物，具有多种药理作用。越来越多的证据表明，延长寿命与身体活动（PA）和睡眠有关，但KMP对这些行为的影响尚不清楚。这项双盲、安慰剂对照、交叉试验评估了KMP对PA和睡眠的影响。
方法
共有33名城市工作者（17名男性和16名女性）参与了本研究。他们被随机分配按照指定顺序服用10毫克KMP或安慰剂，为期2周，中间有7天的洗脱期。所有参与者都佩戴了基于加速度计的可穿戴设备（Fitbit Charge 4），该设备监测每日的PA、心率（HR）以及睡眠期间的HR变异性。
结果
设备佩戴时长为23.73±0.04小时/天。在每个PA水平上HR均下降，与服用安慰剂相比，服用KMP期间每日平均步数和行走距离显著增加。外出率、出行次数、娱乐活动次数以及周末娱乐时间均增加。服用KMP后睡眠质量得到改善。HR的降低和RMSSD的增加可能在介导这些KMP的作用中起重要作用。
结论
KMP导致行为改变，进而改善睡眠质量，并可能改善长期生活质量。
临床试验注册
https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000048447，UMIN000042438。
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