C R Aashik, K Rajapandian, K Gayathri, P L Ravishankar, V Kalaivani, Rao K Sunanda
Periodontology, Sri Ramaswamy Memorial (SRM) Kattankulathur Dental College and Hospital, Chennai, IND.
Cureus. 2024 Jul 18;16(7):e64853. doi: 10.7759/cureus.64853. eCollection 2024 Jul.
Periodontal disease is a host-mediated inflammation caused due to microbial challenge. Hence, mechanisms involving the control of host-associated mediators can be a potential target. The conventional nonsurgical periodontal treatment modality includes scaling and root planing (SRP), which is often combined with adjunctive chemical plaque control agents for effective disease control. Chlorhexidine (CHX) is the most common chemical plaque control agent used. Recent research is now being focused on exploring other medicinal substitutes that may benefit control of inflammation and tissue healing. Folic acid is an important nutrient that increases the ability of oral epithelial cells to resist local irritants and inflammation if supplemented either systemically or locally.
The current study aimed to evaluate the effect of folic acid and CHX mouthwash as an adjunct to scaling and root planing for treating patients with chronic periodontitis.
In this study, 30 patients with chronic periodontitis were included and assigned to either of the two groups: Group A (receiving folic acid-containing mouthrinse) and Group B (receiving CHX mouthrinse). Periodontal measurements, including plaque index, probing pocket depth, gingival index, and healing index, were evaluated at baseline and again four weeks after scaling and root planing.
Significant reduction was detected in all clinical parameters (plaque index, gingival index, probing pocket depth, healing index) for both groups (p<0.05) when evaluated from baseline to four weeks.
Both mouthrinses were effective when used as an adjunct to scaling and root planing in the treatment of periodontitis. Hence, folic acid-containing mouthrinse can be used in patients with chronic periodontitis.
牙周病是由微生物刺激引起的宿主介导的炎症。因此，涉及控制宿主相关介质的机制可能成为潜在的治疗靶点。传统的非手术牙周治疗方法包括龈上洁治和根面平整（SRP），通常还会联合使用辅助性化学菌斑控制剂以有效控制疾病。洗必泰（CHX）是最常用的化学菌斑控制剂。目前的研究正聚焦于探索其他可能有益于炎症控制和组织愈合的药物替代品。叶酸是一种重要的营养素，若全身或局部补充叶酸，可增强口腔上皮细胞抵抗局部刺激和炎症的能力。
本研究旨在评估叶酸和洗必泰漱口水作为龈上洁治和根面平整辅助手段治疗慢性牙周炎患者的效果。
本研究纳入30例慢性牙周炎患者，并将其分为两组：A组（接受含叶酸漱口水）和B组（接受洗必泰漱口水）。在基线时以及龈上洁治和根面平整四周后再次评估牙周指标，包括菌斑指数、探诊深度、牙龈指数和愈合指数。
从基线到四周时评估发现，两组所有临床指标（菌斑指数、牙龈指数、探诊深度、愈合指数）均显著降低（p<0.05）。
两种漱口水作为龈上洁治和根面平整的辅助手段用于治疗牙周炎时均有效。因此，含叶酸漱口水可用于慢性牙周炎患者。
