Pandiyan Indumathy, Rathinavelu Pradeep Kumar, Arumugham Meignana I, D Srisakthi, Balasubramaniam Arthi
Public Health Dentistry, Saveetha Dental College and Hospital, Chennai, IND.
Cureus. 2022 Mar 19;14(3):e23318. doi: 10.7759/cureus.23318. eCollection 2022 Mar.
Mouthwash is the effective chemical plaque control mechanism being practiced globally. Teeth and tongue discoloration, a temporary change in taste perception, an increase in calculus deposits, a burning sensation, and genotoxicity of buccal epithelial cells are all possible side effects. This review evaluates the efficacy of chitosan mouthwash in comparison to chlorhexidine mouthwash in combating plaque accumulation and gingival inflammation. Electronic databases such as Medline, Cochrane, LILACS, TRIP, Google scholar, and clinical trial registries (CTRI) for ongoing trials were searched with appropriate medical subheadings (MeSH) and search terms. Randomized clinical trials comparing the efficacy of chitosan mouthwash and chlorhexidine mouthwash on dental plaque accumulation and gingivitis were included. The outcome variables of interest were plaque index, gingival index, gingival bleeding index, and colony-forming unit (CFU/ml). All data from the included studies were extracted in a customized extraction sheet. The risk of bias across the studies was assessed using the Cochrane tool for intervention (ROB-2), which consisted of six domains. Of the included three studies, we found one study with an overall low risk of bias and two studies with an overall high risk of bias across the domains. Though there was a significant reduction in plaque accumulation, gingival inflammation, and colony-forming units on the use of chitosan mouthwash and chlorhexidine mouthwash separately, all three included studies reported that a combination of both be more effective.
漱口水是全球范围内正在使用的有效的化学菌斑控制方法。牙齿和舌头变色、味觉的暂时改变、牙石沉积增加、烧灼感以及颊黏膜上皮细胞的遗传毒性都是可能的副作用。本综述评估了壳聚糖漱口水与氯己定漱口水在对抗菌斑积聚和牙龈炎症方面的疗效。使用适当的医学主题词（MeSH）和检索词检索了电子数据库，如Medline、Cochrane、LILACS、TRIP、谷歌学术以及正在进行试验的临床试验注册库（CTRI）。纳入了比较壳聚糖漱口水和氯己定漱口水对牙菌斑积聚和牙龈炎疗效的随机临床试验。感兴趣的结局变量为菌斑指数、牙龈指数、牙龈出血指数和菌落形成单位（CFU/ml）。纳入研究的所有数据均在定制的提取表中提取。使用Cochrane干预工具（ROB-2）评估研究中的偏倚风险，该工具由六个领域组成。在纳入的三项研究中，我们发现一项研究的总体偏倚风险较低，两项研究在各个领域的总体偏倚风险较高。尽管单独使用壳聚糖漱口水和氯己定漱口水时，菌斑积聚、牙龈炎症和菌落形成单位均有显著减少，但纳入的三项研究均报告两者联合使用更为有效。
