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一例控制不佳的哮喘青少年合并变应性支气管肺曲霉病及继发性自发性气胸致中央型支气管扩张的病例报告

A Case Report of Central Bronchiectasis in a Poorly Controlled Asthmatic Adolescent With Allergic Bronchopulmonary Aspergillosis and Secondary Spontaneous Pneumothorax.

作者信息

Sravanthi Kasireddy, Jadhav Devika, Tambolkar Sampada, Meshram Shailesh B, Patil Manojkumar G, Mane Shailaja

机构信息

Pediatrics, Dr. D. Y. Patil Medical College, Hospital & Research Centre, Dr. D.Y. Patil Vidyapeeth, Pune, IND.

Respiratory Medicine, Dr. D. Y. Patil Medical College, Hospital & Research Centre, Dr. D.Y. Patil Vidyapeeth, Pune, IND.

出版信息

Cureus. 2024 Jul 18;16(7):e64792. doi: 10.7759/cureus.64792. eCollection 2024 Jul.

DOI:10.7759/cureus.64792
PMID:39156318
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11329887/
Abstract

Allergic bronchopulmonary aspergillosis (ABPA) is a multifaceted immune hypersensitivity reaction occurring in the lungs and bronchi, triggered by exposure and colonization of species, commonly . It typically affects individuals who are immunocompetent but predisposed, such as those with bronchial asthma and cystic fibrosis. Diagnosis involves various methods including chest radiography, computed tomography, identification of eosinophilia, elevated serum IgE (immunoglobulin E) levels, and immunological tests for antigen. Left undiagnosed and untreated, ABPA can advance to bronchiectasis and/or pulmonary fibrosis, leading to significant morbidity and mortality.

摘要

变应性支气管肺曲霉病(ABPA)是一种发生在肺和支气管的多方面免疫超敏反应,由特定菌种的暴露和定植引发,通常为烟曲霉。它通常影响具有免疫能力但易患该病的个体,如患有支气管哮喘和囊性纤维化的患者。诊断涉及多种方法,包括胸部X线摄影、计算机断层扫描、嗜酸性粒细胞增多的识别、血清IgE(免疫球蛋白E)水平升高以及针对曲霉菌抗原的免疫学检测。若未得到诊断和治疗,ABPA可进展为支气管扩张和/或肺纤维化,导致显著的发病率和死亡率。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b053/11329887/58a3f871408d/cureus-0016-00000064792-i05.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b053/11329887/ae0caa3dd29a/cureus-0016-00000064792-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b053/11329887/d9533468ad1f/cureus-0016-00000064792-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b053/11329887/4fd775de3220/cureus-0016-00000064792-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b053/11329887/2b5e11708786/cureus-0016-00000064792-i04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b053/11329887/58a3f871408d/cureus-0016-00000064792-i05.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b053/11329887/ae0caa3dd29a/cureus-0016-00000064792-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b053/11329887/d9533468ad1f/cureus-0016-00000064792-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b053/11329887/4fd775de3220/cureus-0016-00000064792-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b053/11329887/2b5e11708786/cureus-0016-00000064792-i04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b053/11329887/58a3f871408d/cureus-0016-00000064792-i05.jpg

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A randomised trial of prednisolone prednisolone and itraconazole in acute-stage allergic bronchopulmonary aspergillosis complicating asthma.泼尼松龙、泼尼松龙与伊曲康唑治疗哮喘合并急性过敏性支气管肺曲霉病的随机试验。
Eur Respir J. 2021 Sep 9;59(4). doi: 10.1183/13993003.01787-2021. Print 2022 Apr.
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Childhood allergic bronchopulmonary aspergillosis.儿童过敏性支气管肺曲霉病
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