Pierini A, Picchi C, Pisani G, Binanti D, Carli A, Rossi F, Criscuolo M C
Centro Veterinario Pisani-Carli-Chiodo Animalia, via Togliatti 8, 19034 Luni, SP, Italy.
AbLab, Laboratorio di Analisi Veterinarie, via privata Massa Neri, 19038 Sarzana, SP, Italy.
Iran J Vet Res. 2024;25(1):74-78. doi: 10.22099/IJVR.2024.48685.7113.
Penile tumors are rare in dogs and only single case reports or small case series have been reported.
An 11-year-old, cross-breed dog was presented for a two-week history of stranguria. At physical examination, a subcutaneous swelling of the penis was detected. Abdominal radiographs, ultrasonography, and CT showed a subcutaneous penile mass involving the penile urethra and associated with marked lysis of the . Histological features along with the neoplastic cell positivity to CD31 and FVIII immunohistochemical markers warranted a final diagnosis of penile hemangiosarcoma.
FINDINGS/TREATMENT AND OUTCOME: The dog was treated with amputation of the penis, scrotal urethrostomy, and five adjuvant doses of doxorubicin along with thalidomide. Cutaneous and omental metastases were found 235 days after surgery. The dog was euthanized at 296 days due to bone and pulmonary metastasis.
Penile hemangiosarcoma seems to share the same aggressive behavior with other hemangiosarcomas seen in other anatomical locations. Therefore, surgery and chemotherapy may improve survival time in dogs with penile hemangiosarcoma as well.
阴茎肿瘤在犬类中较为罕见，仅有个别病例报告或小病例系列报道。
一只11岁的杂种犬因排尿困难两周前来就诊。体格检查时，发现阴茎有皮下肿胀。腹部X光片、超声检查和CT显示阴茎皮下肿块累及阴茎尿道，并伴有明显的骨质溶解。组织学特征以及肿瘤细胞对CD31和FVIII免疫组化标志物呈阳性，最终确诊为阴茎血管肉瘤。
检查结果/治疗及转归：该犬接受了阴茎截肢、阴囊尿道造口术，并给予五剂阿霉素联合沙利度胺辅助治疗。术后235天发现皮肤和网膜转移。由于骨转移和肺转移，该犬在296天时实施安乐死。
阴茎血管肉瘤似乎与其他解剖部位出现的血管肉瘤具有相同的侵袭性行为。因此，手术和化疗也可能改善阴茎血管肉瘤犬的生存时间。
