局部应用胰岛素治疗青光眼术后结膜缺损：一例报告。

Topical insulin to treat a conjunctival defect after glaucoma surgery: A case report.

作者信息

Burgos-Blasco Barbara, Yeung Sonia N, Docherty Gavin, Iovieno Alfonso

机构信息

Department of Ophthalmology and Visual Sciences, University of British Columbia, Vancouver, Canada.

Department of Surgery, Ophthalmology, Kelowna General Hospital, Kelowna, Canada.

出版信息

Am J Ophthalmol Case Rep. 2024 Jul 22;36:102127. doi: 10.1016/j.ajoc.2024.102127. eCollection 2024 Dec.

DOI:10.1016/j.ajoc.2024.102127

PMID:39156906

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11327544/

Abstract

PURPOSE

Insulin has been postulated as a novel and effective treatment for re-epithelialization of the ocular surface and different pathologies have been suggested as possible indications.

OBSERVATIONS

A 69-year-old diabetic male was referred for a left non-healing conjunctival epithelial defect over the superotemporal scleral patch used in the placement of the Ahmed ClearPath. In the left eye, he was on latanoprost/timolol once daily, prednisolone 1 % once daily and tobramycin/dexamethasone ointment at night. Best-corrected visual acuity was 20/20 in the right eye and 20/25 in the left eye. Slit lamp examination of the left eye showed patches of avascular scleral tissue nasally and superiorly, conjunctival and Tenon defect over a thin avascular scleral patch graft. The patient was started on Humulin insulin 1UI/mL 6 times a day and the defect healed after 3 months of treatment.

CONCLUSIONS AND IMPORTANCE

Insulin eye drops may be used in the treatment of chronic conjunctival epithelial defects following implantation of glaucoma drainage devices.

摘要

目的

胰岛素已被假定为一种用于眼表再上皮化的新型有效治疗方法，并且不同的病理情况已被认为可能是其适用指征。

观察结果

一名69岁的糖尿病男性因在植入艾哈迈德ClearPath时使用的颞上巩膜补片处左侧结膜上皮缺损不愈合前来就诊。左眼，他每天使用一次拉坦前列素/噻吗洛尔，每天一次1%泼尼松龙，晚上使用妥布霉素/地塞米松眼膏。右眼最佳矫正视力为20/20，左眼为20/25。左眼裂隙灯检查显示鼻侧和上方有片状无血管巩膜组织，薄的无血管巩膜补片移植处结膜和眼球筋膜缺损。患者开始每天6次使用优泌林胰岛素1UI/mL，治疗3个月后缺损愈合。