Chebbi Sami, Oueslati Amine, Ben Hadj Alouane Houssem, Kanchel-Lakhoua Fatma, Chabbouh Amel, Ben Rhouma Sami
University of Tunis El Manar, Faculty of Medicine, Habib Thameur Hospital, Urology Department, Tunisia.
University of Tunis El Manar, Faculty of Medicine, Habib Thameur Hospital, Pathology Department, Tunisia.
Urol Case Rep. 2024 Jul 15;56:102802. doi: 10.1016/j.eucr.2024.102802. eCollection 2024 Sep.
Primary urethral melanoma is an exceptionally rare malignancy, comprising a small fraction of melanomas and malignant tumors affecting the female urethra. We report the case of a 74-year-old woman presenting with symptoms initially suggestive of a benign urethral caruncle, which was later diagnosed as nodular melanoma upon histopathological examination. Despite complete surgical excision, subsequent imaging revealed widespread metastases to lymph nodes, liver, lungs, and brain. The patient was promptly referred for systemic therapy. This case highlights the diagnostic challenges and emphasizes the importance of thorough staging and emerging treatment modalities, such as immunotherapy, in managing this aggressive malignancy.
原发性尿道黑色素瘤是一种极其罕见的恶性肿瘤，在影响女性尿道的黑色素瘤和恶性肿瘤中占比很小。我们报告了一例74岁女性病例，其最初症状提示为良性尿道肉阜，经组织病理学检查后确诊为结节性黑色素瘤。尽管进行了完整的手术切除，但随后的影像学检查显示广泛转移至淋巴结、肝脏、肺和脑。该患者被迅速转诊接受全身治疗。本病例突出了诊断挑战，并强调了全面分期以及免疫治疗等新兴治疗方式在管理这种侵袭性恶性肿瘤中的重要性。
