通过AgSCF₃实现α-芳基丙烯酰胺的电化学三氟甲硫基化/环化反应：制备含SCF₃的吲哚酮。
Electrochemical Trifluoromethylthiolation/Cyclization of -Arylacrylamides with AgSCF: Access to SCF-Containing Oxindoles.
作者信息
Wang Yu, Wang Ye, Wang Sheng, Yu Zhou, Wang Siqi, Chen Wenbo
机构信息
Shanghai Key Laboratory of Materials Protection and Advanced Materials in Electric Power, Shanghai University of Electric Power, Shanghai 200090, China.
出版信息
J Org Chem. 2024 Sep 6;89(17):11950-11958. doi: 10.1021/acs.joc.4c00433. Epub 2024 Aug 19.
An environmentally friendly electrochemical strategy for the synthesis of SCF-containing oxindoles was developed. This electrochemical transformation was accomplished through a cascade trifluoromethylthiolation/cyclization of -acrylamides with AgSCF, obviating the requirement for external oxidants. A variety of functional groups were well tolerated in this transformation.
开发了一种用于合成含SCF的氧化吲哚的环境友好型电化学策略。这种电化学转化是通过-丙烯酰胺与AgSCF的级联三氟甲硫基化/环化反应实现的，无需外部氧化剂。多种官能团在该转化反应中具有良好的耐受性。
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