Petrovic Dusan J
Department of Diagnostic Imaging, Center of Radiology and MRI, University Clinical Center of Serbia, Belgrade, Serbia.
Vascular. 2024 Aug 19:17085381241273293. doi: 10.1177/17085381241273293.
The survey aimed to evaluate the precise roles and importance of carotid plaque thickness and carotid intima-media thickness measured in plaque-free areas (PF CC-IMTmean) in future cardiovascular risk prediction.
188 respondents between the age of 46 and 87 divided into two groups (I group - 94 respondents without plaques with CIMT measurement and II Group 94 respondents with carotid plaques; 118 men and 70 women; mean age ± SD, 61.80 ± 5.49) were prospectively examined by the carotid ultrasound Doppler (carotid measurements included plaque thickness PT - nonstenotic plaques (carotid stenosis <50%) and stenotic culprit plaques (carotid stenosis ≥50%), mean CIMT and maximum CIMT). Subjects were followed for 36 months from the inclusion in the study (regular control examinations). Data were recorded on new cases of mortality (CV mortality) and adverse CV events (myocardial infarction - -MI, surgical or endovascular revascularization - coronary or stroke).
In this study, CIMT values vary between 0.62 and 1.43 mm (mean CIMT = 1.21 ± 0.2 mm) while 52 subjects had nonstenotic plaques (14 respondents plaque ulceration, 22 type 2 diabetes mellitus, 38 arterial hypertension) and 38 subjects had stenotic culprit plaques (17 respondents plaque ulceration, 20 type 2 diabetes mellitus, 31 arterial hypertension). After 36 months of follow-up, 76 vascular events were noted (MI, transient ischaemic attack - TIA, stroke and cardiovascular angioplasty or surgery) in this period.
Respondents with carotid plaques had higher cardiovascular events occurrence ( < .01, high statistical difference). Carotid plaques as a parameter have higher predictive vascular event value importance than CIMT. Of note, stenotic plaques, the presence of ulceration on the free surface of the plaque, type 2 diabetes mellitus and hypertension were connected with the highest events occurrence.
本调查旨在评估在未来心血管疾病风险预测中，颈动脉斑块厚度以及在无斑块区域测量的颈动脉内膜中层厚度（PF CC-IMTmean）的精确作用和重要性。
188名年龄在46至87岁之间的受访者被分为两组（I组 - 94名无斑块且进行了CIMT测量的受访者，II组 - 94名有颈动脉斑块的受访者；118名男性和70名女性；平均年龄±标准差，61.80±5.49），通过颈动脉超声多普勒进行前瞻性检查（颈动脉测量包括斑块厚度PT - 非狭窄斑块（颈动脉狭窄<50%）和狭窄责任斑块（颈动脉狭窄≥50%）、平均CIMT和最大CIMT）。从纳入研究开始对受试者进行36个月的随访（定期对照检查）。记录有关死亡新病例（心血管死亡）和不良心血管事件（心肌梗死 - MI、手术或血管内血运重建 - 冠状动脉或中风）的数据。
在本研究中，CIMT值在0.62至1.43毫米之间变化（平均CIMT = 1.21±0.2毫米），而52名受试者有非狭窄斑块（14名受访者有斑块溃疡、22名患有2型糖尿病、38名患有动脉高血压），38名受试者有狭窄责任斑块（17名受访者有斑块溃疡、20名患有2型糖尿病、31名患有动脉高血压）。在36个月的随访期后该期间记录到76起血管事件（MI、短暂性脑缺血发作 - TIA、中风以及心血管血管成形术或手术）。
有颈动脉斑块的受访者发生心血管事件的几率更高（<0.01，具有高度统计学差异）。作为一个参数，颈动脉斑块比CIMT具有更高的预测血管事件价值重要性。值得注意的是，狭窄斑块、斑块游离表面存在溃疡、2型糖尿病和高血压与最高的事件发生率相关。
