Lecturer of Dermatology, Venereology and Andrology Department, Faculty of Medicine, Assiut University Hospitals, Assiut, 71515, Egypt.
Arch Dermatol Res. 2024 Aug 19;316(8):537. doi: 10.1007/s00403-024-03226-3.
In treating post-traumatic scars, this study compared the safety and effectiveness of combined subcision with saline and microneedling versus combined subcision with platelet-rich plasma and microneedling. Combined subcision with saline and microneedling or combined subcision with platelet-rich plasma and microneedling were used to treat 36 consecutive individuals with post-traumatic scarring. The Modified Manchester score was used to assess texture change, pigmentation, and surface distortion changes. Each change was given a score between 1 and 4. A lower score (range: 3-12) indicates a better result. The mean of the three individual scores was determined. For best outcomes, each patient needed four treatment sessions for each scar, with a one-month follow-up period following the final treatment. The three variables in group B had mean scores of 1.4 ± 0.5, 2 ± 0.8, and 2.2 ± 0.9, respectively, for texture change, pigmentation, and surface distortion. With a mean score of 1.4 ± 0.5, texture change had the best response out of the three variables we evaluated. The investigator determined that the mean improvement score for patients in group B's overall appearance was 5.61 ± 1.19. The study has shown that the combination of subcision with platelet-rich plasma, and microneedling appears to be a promising treatment for posttraumatic scars due to its low risk and high efficacy. Our findings suggest that this is a safe method for treating posttraumatic scars, with few side effects and a low chance of recurrence.
04-2023-300279.
NCT06135480.
在治疗创伤后疤痕方面，本研究比较了联合切除加生理盐水和微针与联合切除加富血小板血浆和微针治疗创伤后疤痕的安全性和有效性。联合切除加生理盐水和微针或联合切除加富血小板血浆和微针用于治疗 36 例连续创伤后疤痕患者。采用改良曼彻斯特评分评估纹理变化、色素沉着和表面畸形变化。每个变化的评分在 1 到 4 之间。评分越低（范围 3-12）表示结果越好。三个个体评分的平均值。为获得最佳效果，每个患者每个疤痕需要进行四次治疗，最后一次治疗后进行为期一个月的随访。B 组的三个变量的平均评分为纹理变化 1.4±0.5、色素沉着 2±0.8 和表面畸形 2.2±0.9。纹理变化的平均评分为 1.4±0.5，在我们评估的三个变量中反应最好。研究者确定 B 组患者整体外观的平均改善评分是 5.61±1.19。该研究表明，联合切除加富血小板血浆和微针治疗创伤后疤痕的风险低、效果高，似乎是一种有前途的治疗方法。我们的研究结果表明，这是一种治疗创伤后疤痕的安全方法，副作用少，复发率低。
IRB 本地批准编号：04-2023-300279。
NCT06135480。
