Department of Pediatrics, Islamic Azad University of Yazd, Yazd, Iran.
Neonatal Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
Fetal Pediatr Pathol. 2024 Sep-Oct;43(5):399-418. doi: 10.1080/15513815.2024.2390932. Epub 2024 Aug 19.
This study aims to explore the association between variations in the Surfactant Protein-B (SFTPB) gene and the risk of neonatal respiratory distress syndrome (NRDS).
A comprehensive literature search was conducted across PubMed, Scopus, EMBASE, and CNKI databases up to February 10, 2024, to identify pertinent studies.
A total of seventeen studies examining the +1580 C/T polymorphism (2,058 cases and 2,596 controls) and five studies investigating the -18 A/C polymorphism (680 cases and 739 controls) were included in the analysis. The pooled data indicated that the +1580 C/T polymorphism confers a protective effect against NRDS in various populations and ethnic groups. Conversely, the -18 A/C polymorphism did not demonstrate a significant association either globally or among Asian neonates.
The +1580 C/T variant appears to be protective against NRDS, whereas the -18 A/C polymorphism shows minimal impact on the disease's progression.
本研究旨在探讨表面活性蛋白-B（SFTPB）基因变异与新生儿呼吸窘迫综合征（NRDS）风险之间的关联。
对 PubMed、Scopus、EMBASE 和中国知网（CNKI）数据库进行全面文献检索，检索时间截至 2024 年 2 月 10 日，以确定相关研究。
共纳入 17 项研究，分析了 +1580C/T 多态性（2058 例病例和 2596 例对照），纳入 5 项研究，分析了-18A/C 多态性（680 例病例和 739 例对照）。汇总数据表明，+1580C/T 多态性在不同人群和种族中均对 NRDS 具有保护作用。相反，-18A/C 多态性在全球或亚洲新生儿中均与 NRDS 无显著关联。
+1580C/T 变异似乎对 NRDS 具有保护作用，而-18A/C 多态性对疾病的进展影响较小。
