关于表面活性蛋白-B（SFTPB）多态性与新生儿呼吸窘迫综合征易感性关系的综合数据汇编。

A Comprehensive Compilation of Data on the Relationship Between Surfactant Protein-B (SFTPB) Polymorphisms and Susceptibility to Neonatal Respiratory Distress Syndrome.

机构信息

Department of Pediatrics, Islamic Azad University of Yazd, Yazd, Iran.

Neonatal Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.

出版信息

Fetal Pediatr Pathol. 2024 Sep-Oct;43(5):399-418. doi: 10.1080/15513815.2024.2390932. Epub 2024 Aug 19.

DOI:10.1080/15513815.2024.2390932

PMID:39159013

Abstract

BACKGROUND

This study aims to explore the association between variations in the Surfactant Protein-B (SFTPB) gene and the risk of neonatal respiratory distress syndrome (NRDS).

METHODS

A comprehensive literature search was conducted across PubMed, Scopus, EMBASE, and CNKI databases up to February 10, 2024, to identify pertinent studies.

RESULTS

A total of seventeen studies examining the +1580 C/T polymorphism (2,058 cases and 2,596 controls) and five studies investigating the -18 A/C polymorphism (680 cases and 739 controls) were included in the analysis. The pooled data indicated that the +1580 C/T polymorphism confers a protective effect against NRDS in various populations and ethnic groups. Conversely, the -18 A/C polymorphism did not demonstrate a significant association either globally or among Asian neonates.

CONCLUSIONS

The +1580 C/T variant appears to be protective against NRDS, whereas the -18 A/C polymorphism shows minimal impact on the disease's progression.

摘要

背景

本研究旨在探讨表面活性蛋白-B（SFTPB）基因变异与新生儿呼吸窘迫综合征（NRDS）风险之间的关联。

方法

对 PubMed、Scopus、EMBASE 和中国知网（CNKI）数据库进行全面文献检索，检索时间截至 2024 年 2 月 10 日，以确定相关研究。

结果

共纳入 17 项研究，分析了 +1580C/T 多态性（2058 例病例和 2596 例对照），纳入 5 项研究，分析了-18A/C 多态性（680 例病例和 739 例对照）。汇总数据表明，+1580C/T 多态性在不同人群和种族中均对 NRDS 具有保护作用。相反，-18A/C 多态性在全球或亚洲新生儿中均与 NRDS 无显著关联。