全面整理关于表面活性蛋白-B（SFTPB）多态性与支气管肺发育不良易感性之间关系的数据。
A Comprehensive Consolidation of Data on the Relationship Between Surfactant Protein-B (SFTPB) Polymorphisms and Susceptibility to Bronchopulmonary Dysplasia.
机构信息
Neonatal Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
Department of Pediatrics, Islamic Azad University of Yazd, Yazd, Iran.
出版信息
Fetal Pediatr Pathol. 2024 Nov-Dec;43(6):436-454. doi: 10.1080/15513815.2024.2400145. Epub 2024 Sep 8.
BACKGROUND
This meta-analysis aims to evaluate the potential link between common variations in the Surfactant Protein-B (SFTPB) gene and the risk of bronchopulmonary dysplasia (BPD) in preterm neonates.
METHODS
All pertinent articles published prior to February 1, 2024, in PubMed, Web of Science, EMBASE, CNKI, and Scopus databases were reviewed.
RESULTS
Nineteen case-control studies involving 1149 BPD cases and 1845 non-BPD controls, were analyzed. Combined data indicated a significant link between SFTPB -18 A > C and Intron 4 VNTR polymorphisms with increased BPD susceptibility, while the 1580 C > T polymorphism provides a protective impact on BPD initiation.
CONCLUSIONS
Pooled data indicated a significant association between SFTPB -18 A > C and Intron 4 VNTR polymorphisms with increased BPD risk, whereas the 1580 C > T polymorphism confers protection. These findings suggest a genetic susceptibility to BPD, underscoring the complex interplay of different genetic elements in its development.
背景
本荟萃分析旨在评估表面活性蛋白-B（SFTPB）基因常见变异与早产儿支气管肺发育不良（BPD）风险之间的潜在关联。
方法
检索 PubMed、Web of Science、EMBASE、CNKI 和 Scopus 数据库中截至 2024 年 2 月 1 日之前发表的所有相关文章。
结果
共纳入 19 项病例对照研究，包括 1149 例 BPD 病例和 1845 例非 BPD 对照。合并数据表明，SFTPB-18A>C 和内含子 4VNTR 多态性与 BPD 易感性增加显著相关，而 1580C>T 多态性对 BPD 的发生具有保护作用。
结论
汇总数据表明，SFTPB-18A>C 和内含子 4VNTR 多态性与 BPD 风险增加显著相关，而 1580C>T 多态性具有保护作用。这些发现提示 BPD 存在遗传易感性，强调了不同遗传因素在其发生发展中的复杂相互作用。
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