Department of Chemical Engineering, <a href="https://ror.org/02t274463">University of California, Santa Barbara</a>, Santa Barbara, California 93106, USA.
Phys Rev E. 2024 Jul;110(1-1):014410. doi: 10.1103/PhysRevE.110.014410.
We study the dynamic structure of lipid domain inclusions embedded within a phase-separated reconstituted lipid bilayer in contact with a swarming flow of gliding filamentous actin. Passive circular domains transition into highly deformed morphologies that continuously elongate, rotate, and pinch off into smaller fragments, leading to a dynamic steady state with ≈23× speedup in the relaxation of the intermediate scattering function compared with passive membrane domains driven by purely thermal forces. To corroborate experimental results, we develop a phase-field model of the lipid domains with two-way coupling to the Toner-Tu equations. We report phase domains that become entrained in the chaotic eddy patterns, with oscillating waves of domains that correlate with the dominant wavelengths of the Toner-Tu flow fields.
我们研究了嵌入在与滑行丝状肌动蛋白 swarm 流接触的相分离再组装脂质双层中的脂质域包含物的动态结构。被动的圆形域转变为高度变形的形态，这些形态不断伸长、旋转，并分裂成更小的碎片，导致中间散射函数的弛豫速度比仅受热力学驱动的被动膜域快约 23 倍，达到动态稳定状态。为了证实实验结果，我们针对脂质域开发了一个具有双向 Toner-Tu 方程耦合的相场模型。我们报告了被卷入混沌涡流模式的相域，以及与 Toner-Tu 流场的主导波长相关的域的振荡波。
