Department of Gynecology and Obstetrics, Clinical Medical College and The First Affiliated Hospital of Chengdu Medical College, Chengdu, Sichuan, China.
Med Sci Monit. 2024 Aug 20;30:e944556. doi: 10.12659/MSM.944556.
BACKGROUND Previous studies have suggested that autophagy, a cellular process regulated by ATG7, plays a critical role in ovarian physiology and pathology. In this study, our objective was to examine ATG7 levels in women with and without polycystic ovary syndrome (PCOS) and to explore potential associations between serum ATG7 levels and PCOS. MATERIAL AND METHODS The study included 188 women diagnosed with PCOS, matched with an equal number of healthy women for comparison. Serum levels of ATG7 were determined using the ELISA technique, and the difference was assessed using an independent samples t test. The association between ATG7 serum levels and the risk of developing PCOS was evaluated by using a multivariable logistic regression model. Additionally, the potential of ATG7 to predict PCOS was investigated through logistic regression and receiver operating characteristic (ROC) analysis. RESULTS Our study found that women with PCOS had significantly lower serum ATG7 levels than their healthy counterparts. Lower ATG7 levels were associated with a higher risk of developing PCOS after adjusting for various confounding variables. The combination of ATG7 with HOMA-IR performed well in predicting PCOS, with an AUC of 92.3%, a sensitivity of 88.3%, and a specificity of 85.3%. CONCLUSIONS Our study found that serum ATG7 levels were significantly lower in women with PCOS and were associated with an increased risk of developing PCOS. This suggests that ATG7 could potentially serve as a biomarker for diagnosing and managing PCOS.
先前的研究表明，自噬是一种由 ATG7 调控的细胞过程，在卵巢生理学和病理学中起着关键作用。在这项研究中，我们的目的是检查多囊卵巢综合征（PCOS）患者和非 PCOS 患者的 ATG7 水平，并探讨血清 ATG7 水平与 PCOS 之间的潜在关联。
该研究纳入了 188 名被诊断为 PCOS 的女性，并与相同数量的健康女性进行了匹配。使用 ELISA 技术测定血清 ATG7 水平，并使用独立样本 t 检验评估差异。使用多变量逻辑回归模型评估 ATG7 血清水平与发生 PCOS 的风险之间的关联。此外，通过逻辑回归和接收者操作特征（ROC）分析研究了 ATG7 预测 PCOS 的潜力。
我们的研究发现，PCOS 患者的血清 ATG7 水平明显低于健康对照组。在调整了各种混杂变量后，较低的 ATG7 水平与发生 PCOS 的风险增加相关。ATG7 与 HOMA-IR 的组合在预测 PCOS 方面表现良好，AUC 为 92.3%，敏感性为 88.3%，特异性为 85.3%。
我们的研究发现，PCOS 患者的血清 ATG7 水平明显降低，并且与发生 PCOS 的风险增加相关。这表明 ATG7 可能可作为诊断和管理 PCOS 的生物标志物。
