Suppr超能文献

比较不同性别、物种和纹状体亚区的多巴胺释放和摄取参数。

Comparison of dopamine release and uptake parameters across sex, species and striatal subregions.

机构信息

Department of Translational Neuroscience, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA.

Department of Biomedical Engineering, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA.

出版信息

Eur J Neurosci. 2024 Sep;60(6):5113-5140. doi: 10.1111/ejn.16495. Epub 2024 Aug 19.

Abstract

For over four decades, fast-scan cyclic voltammetry (FSCV) has been used to selectively measure neurotransmitters such as dopamine (DA) with high spatial and temporal resolution, providing detailed information about the regulation of DA in the extracellular space. FSCV is an optimal method for determining concentrations of stimulus-evoked DA in brain tissue. When modelling diseases involving disturbances in DA transmission, preclinical rodent models are especially useful because of the availability of specialized tools and techniques that serve as a foundation for translational research. There is known heterogeneity in DA dynamics between and within DA-innervated brain structures and between males and females. However, systematic evaluations of sex- and species-differences across multiple areas are lacking. Therefore, using FSCV, we captured a broad range of DA dynamics across five sub-regions of the dorsal and ventral striatum of males and females of both rats and mice that reflect the functional heterogeneity of DA kinetics and dynamics within these structures. While numerous differences were found, in particular, we documented a strong, consistent pattern of increased DA transporter activity in females in all of the regions surveyed. The data herein are intended to be used as a resource for further investigation of DA terminal function.

摘要

四十多年来,快速扫描循环伏安法(FSCV)一直被用于以高时空分辨率选择性测量神经递质,如多巴胺(DA),提供关于细胞外空间中 DA 调节的详细信息。FSCV 是确定脑组织中刺激诱发的 DA 浓度的最佳方法。在涉及 DA 传递障碍的疾病建模中,由于具有专门的工具和技术,啮齿动物的临床前模型特别有用,这些工具和技术为转化研究奠定了基础。已知 DA 动力学在 DA 神经支配的脑结构之间和内部以及雄性和雌性之间存在异质性。然而,缺乏对多个区域的性别和物种差异的系统评估。因此,我们使用 FSCV 在雄性和雌性大鼠和小鼠的背侧和腹侧纹状体的五个亚区中捕获了广泛的 DA 动力学,这些动力学反映了这些结构中 DA 动力学和动力学的功能异质性。虽然发现了许多差异,但特别是,我们在所有被调查的区域都记录到了女性中 DA 转运体活性增加的强烈一致模式。本文中的数据旨在用作进一步研究 DA 末端功能的资源。

文献AI研究员

20分钟写一篇综述,助力文献阅读效率提升50倍。

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

文档翻译

学术文献翻译模型,支持多种主流文档格式。

立即体验