胰腺内脂肪沉积对急性和慢性胰腺炎的因果效应：一项孟德尔随机化研究
The Causal Effect of Intrapancreatic Fat Deposition on Acute and Chronic Pancreatitis: A Mendelian Randomization Study.
作者信息
Yamazaki Hajime, Heni Martin, Wagner Róbert, Fukuhara Shunichi, Grossman Steven R, Han Sihao, Wu Lang, Streicher Samantha A, Huang Brian Z
机构信息
Department of Community Medicine, Section of Clinical Epidemiology, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Center for Innovative Research for Communities and Clinical Excellence (CiRC2LE), Fukushima Medical University, Fukushima, Japan.
出版信息
Am J Gastroenterol. 2024 Dec 1;119(12):2540-2544. doi: 10.14309/ajg.0000000000003048. Epub 2024 Aug 20.
INTRODUCTION
Recent associative studies have linked intrapancreatic fat deposition (IPFD) with risk of pancreatitis, but the causal relationship remains unclear.
METHODS
Using Mendelian randomization, we evaluated the causal association between genetically predicted IPFD and pancreatitis. This approach used genetic variants from genomewide association studies of IPFD (n = 25,617), acute pancreatitis (n = 6,787 cases/361,641 controls), and chronic pancreatitis (n = 3,875 cases/361,641 controls).
RESULTS
Genetically predicted IPFD was significantly associated with acute pancreatitis (odds ratio per 1-SD increase: 1.40 [95% CI: 1.12-1.76], P = 0.0032) and chronic pancreatitis (odds ratio: 1.64 [95% CI: 1.13-2.39], P = 0.0097).
DISCUSSION
Our findings support a causal role of IPFD in pancreatitis, suggesting that reducing IPFD could lower the risk of pancreatitis.
引言
近期的关联研究已将胰腺内脂肪沉积（IPFD）与胰腺炎风险联系起来，但因果关系仍不明确。
方法
我们采用孟德尔随机化方法，评估了基因预测的IPFD与胰腺炎之间的因果关联。该方法使用了来自IPFD全基因组关联研究（n = 25,617）、急性胰腺炎（n = 6,787例/361,641例对照）和慢性胰腺炎（n = 3,875例/361,641例对照）的基因变异。
结果
基因预测的IPFD与急性胰腺炎（每增加1个标准差的比值比：1.40 [95%可信区间：[i]1.12 - 1.76[/i]，P = 0.0032）和慢性胰腺炎（比值比：1.64 [95%可信区间：1.13 - 2.39]，P = 0.oo97）显著相关。
讨论
我们的研究结果支持IPFD在胰腺炎中起因果作用，提示降低IPFD可能会降低胰腺炎风险。
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